Evidence map›Paper›PMID 41540282›Full record

ReviewJournal of molecular medicine (Berlin, Germany)2026

cGAS-STING signaling pathway in MASLD and liver fibrosis.

Yang Xiao, Yufang Ma, Can Gan, Zhiyin Huang, Jinhang Gao

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of molecular medicine (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yang Xiao *Laboratory of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, China.
Yufang Ma *Laboratory of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, China.
Can GanLaboratory of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, China.
Zhiyin HuangLaboratory of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, China. huangzy911@163.com.
Jinhang GaoLaboratory of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, China. Gao.jinhang@scu.edu.cn.ORCID http://orcid.org/0000-0003-0480-7867

Funding

Key Research and Development Program of Sichuan Province 2023YFS0114Key Research and Development Program of Sichuan Province 2025YFHZ0120the 135 projects for disciplines of excellence of West China Hospital, Sichuan University ZYGD23029the 135 projects for disciplines of excellence of West China Hospital, Sichuan University ZYYC23026the National Natural Science Fund of China 82170623the National Natural Science Fund of China 82170625the National Natural Science Fund of China 82300711the National Natural Science Fund of China 82322011the National Natural Science Fund of China 82470648
6 · The paper itself

Abstract

In metabolic dysfunction-associated steatotic liver disease (MASLD), lipid accumulation and inflammatory stimulation lead to the release of damage-associated molecular patterns, thereby inducing the activation of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway. The cGAS-STING signaling pathway in the liver is primarily activated in Kupffer cells/macrophages, hepatic stellate cells, hepatocytes and liver sinusoidal endothelial cells. Emerging evidence also reveals that the cGAS-STING signaling pathway contributes to liver cell fate changes in MASLD. Herein, this review summarizes the role of the cGAS-STING signaling pathway in liver cells and its effect on cell fate in the context of MASLD and liver fibrosis. Therapeutic agents targeting the cGAS-STING signaling pathway may shed light on the clinical treatment of MASLD and liver fibrosis.

Indexed as

Liver CirrhosisMembrane ProteinsNucleotidyltransferasesSignal TransductionAnimalscGAS-STING Signaling PathwayCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseHepatic Stellate CellsHumansLiverSTING ProteincGAS protein, humanCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseMembrane ProteinsNucleotidyltransferasesSTING1 protein, humanSTING ProteinCell fateHepatic stellate cellsHepatocytesLiver sinusoidal endothelial cellsMacrophagesMASH

Identifiers

PMID41540282

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.