ArticleNature neuroscience2026
Investigating the methodological foundation of lesion network mapping.
Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Neuroanatomical correlates of stroke-related dizziness and vertigo: secondary analysis from the INSPiRE-TMS trial.Journal of neurology · 2026Trial
- Neuromodulation for restoring and amplifying brain function.Nature neuroscience · 2026Review
- Considering biological limitations of lesion network mapping.Nature neuroscience · 2026Article
- Convergence of TMS Sites and Lesion Locations Associated With Nicotine Addiction Improvement on a Common Brain Circuit.The American journal of psychiatry · 2026Article
- Harmonized Acquisition of Connectome MRI and Clinical Data for Stroke, Parkinson's Disease and Glioma: Delphi-Derived Protocol Recommendations by the European Academy of Neurology.European journal of neurology · 2026Review
- Article
- Robust lesion network mapping reveals genuine symptom-specific networks.bioRxiv : the preprint server for biology · 2026Article
- Null models for lesion network mapping.Nature neuroscience · 2026Article
- Multimodal network localization of brain abnormalities and neuromodulation target identification in obsessive-compulsive disorder.Scientific reports · 2026Article
- The methodological foundations of lesion network mapping remain sound.bioRxiv : the preprint server for biology · 2026Article
- Systemic neuropsychology: toward a contemporary theory of topological functional systems.Frontiers in psychiatry · 2026Review
- Brain structural and functional damage network localization of COVID-19 survivors.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Lesion network mapping (LNM) is a neuroimaging framework that uses normative functional connectivity (FC) data to link heterogeneous brain lesions and functional alterations to brain networks implicated in neurological and psychiatric conditions. However, many of the networks identified by LNM and related methods appear to be highly similar across diverse conditions such as addiction, depression, psychosis and epilepsy. To understand this similarity, we re-examined the data from multiple LNM studies and assessed the methodological roots of the method. Our findings reveal a foundational limitation: at its core, LNM involves a repetitive sampling of one and the same FC matrix. As a result, it systematically maps sets of local brain changes-whether they are patient lesions, magnetic resonance imaging-derived alterations, synthetic or random-onto the same nonspecific properties of the used FC data, producing highly similar networks across conditions. This central limitation cautions the use of LNM as a method for studying distinct biological networks underlying brain disorders. Our work may aid the development of a new generation of network-mapping methods from first principles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.