Evidence map›Paper›PMID 41540236›Full record

ArticleNature materials2026

Electrogenic protein condensates as intracellular electrochemical reactors.

Wen Yu, Yuefeng Ma, Leshan Yang, Yanrun Zhou, Xinrui Liu, Yifan Dai

Abstract read
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In one paragraph

Article in Nature materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Origins of the Intrinsic Redox Activity of Biomolecular Condensates.Journal of the American Chemical Society · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wen Yu *Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0003-4613-4525
Yuefeng Ma *Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.
Leshan YangDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.
Yanrun ZhouDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0009-0009-3570-6138
Xinrui LiuDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0009-0000-2319-8265
Yifan DaiDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA. dyifan@wustl.edu.ORCID 0000-0002-1009-5790

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Charged surfaces in aqueous solution establish electric double layers that modulate interfacial electron transfer and drive redox chemistry. However, the capability to engineer the interfacial electrochemical environments of soft biomaterials to enable electron generation for chemical reactions has not been realized. Here we show that genetically encoded biomaterials that can undergo self-assembly into protein condensates can be engineered to function as electrochemical reactors. We establish the fundamental principles that govern the sequence-electrochemical property relationship of protein condensates, thereby programming their electrogenic behaviours. We demonstrate the applications of protein condensates in various electrochemical reactions in vitro. We also deploy these condensates in biological cells as living materials for intracellular nanoparticle synthesis, pollutant degradation and antibiotic-free inhibition of bacteria through artificial ferroptosis. These intrinsic electrogenic materials offer a biomaterial platform that could be used as a clean and sustainable energy source for the development of next-generation bioelectrochemical devices.

Indexed as

Biomolecular CondensatesElectrochemical TechniquesProteinsNanoparticlesProteins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.