Synthesis, characterization, and lipoxygenase inhibition of salicylaldehyde-derived schiff base metal complexes: enzymatic and in silico evaluation using quinoa lipoxygenase.

Ergün Ereminsoy, Yeliz Demir, Sümeyra Tuna Yıldırım, Cüneyt Türkeş, Ömer İrfan Küfrevioğlu

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Ergün EreminsoyDepartment of Chemistry, Faculty of Science, Atatürk University, Erzurum, 25240, Türkiye.

Yeliz DemirDepartment of Pharmacy Services, Nihat Delibalta Göle Vocational High School, Ardahan University, Ardahan, 75700, Türkiye. yelizdemir2116@gmail.com.

Sümeyra Tuna YıldırımDepartment of Analytical Chemistry, Faculty of Pharmacy, Erzincan Binali Yıldırım University, Erzincan, 24002, Türkiye.

Cüneyt TürkeşDepartment of Biochemistry, Faculty of Pharmacy, Erzincan Binali Yıldırım University, Erzincan, 24002, Türkiye.

Ömer İrfan KüfrevioğluDepartment of Chemistry, Faculty of Science, Atatürk University, Erzurum, 25240, Türkiye. okufrevi@atauni.edu.tr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present study, novel Schiff base ligands were synthesized via the condensation of salicylaldehyde derivatives with o-aminophenol, and their metal complexes with Co(II), Ni(II), Cu(II), Zn(II), Cd(II), and UO₂(VI) metal actetates were successfully prepared. The compounds were comprehensively characterized using FT-IR,

Indexed as

AldehydesCoordination ComplexesLipoxygenaseLipoxygenase InhibitorsMolecular Docking SimulationSchiff BasesAldehydesCoordination ComplexesLipoxygenaseLipoxygenase InhibitorssalicylaldehydeSchiff BasesCharacterizationLipoxygenaseMetal complexesMolecular dockingSchiff base

Identifiers

PMID41540217

DOI10.1007/s00210-025-04955-6

PMCPMC13086667

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.