Evidence map›Paper›PMID 41540136›Full record

ArticleScientific reports2026

Chemical synthesis, bioinformatics and antiproliferative studies of novel pyrimidin-4-yl-1H-pyrazole derivatives in chronic myeloid cancer cells.

K V Rajasheker, M S Pallavi, P C Arun, Victor Stupin, Muzaffar Iqbal, Catarina Roma-Rodrigues, Pedro V Baptista, Alexandra R Fernandes, Ekaterina Silina, Shiva Prasad Kollur

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

K V RajashekerSchool of Physical Sciences, Amrita Vishwa Vidyapeetham, Mysuru Campus, Mysuru, Karnataka, 570 026, India.
M S PallaviSchool of Computing, Amrita Vishwa Vidyapeetham, Mysuru Campus, Mysuru, Karnataka, 570 026, India.
P C ArunAurigene Pharmaceuticals (APSL), Electronic City, Bengaluru, Karnataka, 560 100, India.
Victor StupinDepartment of Surgery, Pirogov Russian National Research Medical University, Moscow, Russia, 117997.
Muzaffar IqbalDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, 11451, Riyadh, Saudi Arabia.
Catarina Roma-RodriguesApplied Molecular Biosciences Unit (UCIBIO), Departamento de Ciências da Vida, NOVA School of Science and Technology, NOVA University Lisbon, 2829-516, Caparica, Portugal.
Pedro V BaptistaApplied Molecular Biosciences Unit (UCIBIO), Departamento de Ciências da Vida, NOVA School of Science and Technology, NOVA University Lisbon, 2829-516, Caparica, Portugal.
Alexandra R FernandesApplied Molecular Biosciences Unit (UCIBIO), Departamento de Ciências da Vida, NOVA School of Science and Technology, NOVA University Lisbon, 2829-516, Caparica, Portugal. ma.fernandes@fct.unl.pt.
Ekaterina SilinaInstitute of Digital Biodesign and Modeling of Living Systems, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia, 119991. silinaekaterina@mail.ru.
Shiva Prasad KollurSchool of Physical Sciences, Amrita Vishwa Vidyapeetham, Mysuru Campus, Mysuru, Karnataka, 570 026, India. shivachemist@gmail.com.

Funding

Fundação para a Ciência e a Tecnologia DOI:10.54499/UIDP/04378/2020 and DOI:10.54499/UIDB/04378/2020King Saud University, Riyadh ORF-2025-734UCIBIO LA/P/0140/2020
6 · The paper itself

Abstract

A series of novel methyl-1-(2-((3,5-dimethylphenyl)amino)pyrimidin-4-yl)-1H-pyrazole derivatives were synthesized, characterized through

Indexed as

Antineoplastic AgentsLeukemia, Myelogenous, Chronic, BCR-ABL PositivePyrazolesPyrimidinesCell Line, TumorCell ProliferationComputational BiologyDrug Resistance, NeoplasmDrug Screening Assays, AntitumorHumansImatinib MesylateK562 CellsMolecular Docking SimulationAntineoplastic AgentsImatinib MesylatePyrazolesPyrimidinesAntiproliferative drugsImatinibK562 cellsPyrimidineSDG 3

Identifiers

PMID41540136
PMCPMC12816615

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.