Evidence map›Paper›PMID 41540118›Full record

ArticleNPJ digital medicine2026

Remote digital cognitive assessment for aging and dementia using the Oxford Cognitive Testing Portal OCTAL.

Sijia Zhao, Sofia Toniolo, Qian-Yuan Tang, Anna Scholcz, Akke Ganse-Dumrath, Claudia Gendarini, M John Broulidakis, Sian Thompson, Sanjay G Manohar, Masud Husain

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Article in NPJ digital medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Sijia Zhao *Department of Experimental Psychology, University of Oxford, Oxford, UK. sijia.zhao@psy.ox.ac.uk.
Sofia Toniolo *Cognitive Disorders Clinic, John Radcliffe Hospital, Oxford, UK.
Qian-Yuan TangDepartment of Physics, Hong Kong Baptist University, Hong Kong, China.
Anna ScholczDepartment of Experimental Psychology, University of Oxford, Oxford, UK.
Akke Ganse-DumrathDepartment of Experimental Psychology, University of Oxford, Oxford, UK.
Claudia GendariniCognitive Disorders Clinic, John Radcliffe Hospital, Oxford, UK.
M John BroulidakisDepartment of Experimental Psychology, University of Oxford, Oxford, UK.
Sian ThompsonCognitive Disorders Clinic, John Radcliffe Hospital, Oxford, UK.
Sanjay G ManoharDepartment of Experimental Psychology, University of Oxford, Oxford, UK.
Masud HusainDepartment of Experimental Psychology, University of Oxford, Oxford, UK.

Funding

Medical Research Council MR/P00878/XWellcome Trust 226645/Z/22/Z
6 · The paper itself

Abstract

The global rise in dementia necessitates scalable cognitive assessments that can evolve to serve both clinical and research applications. We present the Oxford Cognitive Testing Portal (OCTAL), a remote, browser-based platform providing performance metrics for memory, attention, visuospatial and executive function domains. Four validation studies (N = 1664) confirmed cross-cultural applicability, lifespan sensitivity and clinical utility. Task performance was equivalent in English- and Chinese-speaking younger adults and mapped domain-specific ageing trajectories in mid- to late-adulthood. In a memory-clinic cohort (N = 194), 5-minute OCTAL screen distinguished patients with Alzheimer's disease dementia from subjective cognitive decline (AUC = 0.92), matching a standard paper-based test, while a 20-minute subset surpassed this (AUC = 0.97; p = 0.04). Test-retest reliability was very good (ICC ≥ 0.79; N = 118). OCTAL enables remote assessment for large-scale research and screening, with an open, modular architecture that makes it a uniquely sustainable and evolvable tool for the research community.

Identifiers

PMID41540118
PMCPMC12909784

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