Evidence map›Paper›PMID 41540043›Full record

ArticleNPJ Parkinson's disease2026

Low-frequency activity in the subthalamic nucleus informs about the acute neuropsychiatric state in Parkinson's disease.

Elena Bernasconi, Alberto Averna, Valentina D'Onofrio, Deborah Amstutz, Damian M Herz, Laura Alva, Andreia D Magalhães, Katrin Petermann, Ines Debove, M Lenard Lachenmayer and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Elena BernasconiDepartment of Neurology, Bern University Hospital and University of Bern, Bern, Switzerland, Bern, Switzerland.
Alberto AvernaDepartment of Neurology, Bern University Hospital and University of Bern, Bern, Switzerland, Bern, Switzerland.
Valentina D'OnofrioPadova Neuroscience Center, University of Padua, Padua, Italy.
Deborah AmstutzDepartment of Neurology, Bern University Hospital and University of Bern, Bern, Switzerland, Bern, Switzerland.
Damian M HerzDepartment of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
Laura AlvaDepartment of Neurology, Bern University Hospital and University of Bern, Bern, Switzerland, Bern, Switzerland.
Andreia D MagalhãesDepartment of Neurology, Bern University Hospital and University of Bern, Bern, Switzerland, Bern, Switzerland.
Katrin PetermannDepartment of Neurology, Bern University Hospital and University of Bern, Bern, Switzerland, Bern, Switzerland.
Ines DeboveDepartment of Neurology, Bern University Hospital and University of Bern, Bern, Switzerland, Bern, Switzerland.
M Lenard LachenmayerDepartment of Neurology, Bern University Hospital and University of Bern, Bern, Switzerland, Bern, Switzerland.
Andreas NowackiDepartment of Neurosurgery, Bern University Hospital and University of Bern, Bern, Switzerland.
Claudio PolloDepartment of Neurosurgery, Bern University Hospital and University of Bern, Bern, Switzerland.
Paul KrackDepartment of Neurology, Bern University Hospital and University of Bern, Bern, Switzerland, Bern, Switzerland.
Mario SousaDepartment of Neurology, Bern University Hospital and University of Bern, Bern, Switzerland, Bern, Switzerland.
Gerd TinkhauserDepartment of Neurology, Bern University Hospital and University of Bern, Bern, Switzerland, Bern, Switzerland. gerd.tinkhauser@insel.ch.

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung PZ00P3_202166
6 · The paper itself

Abstract

Sensing-guided deep brain stimulation (DBS) offers potential to further optimize symptom control in Parkinson's disease (PD) patients. Emerging evidence suggests that basal ganglia signals reflect not only motor, but also chronic neuropsychiatric symptoms. However, it remains unclear whether local field potentials (LFPs) can inform about acute neuropsychiatric states in PD, which we address in this work. Fourteen PD patients implanted with a brain-sense-enabled neurostimulator underwent an acute levodopa challenge OFF/ON stimulation one year after surgery. In each condition, resting state STN-LFPs were recorded, and the acute neuropsychiatric state was evaluated using the Neuropsychiatric Fluctuation Scale. The relationship between neuropsychiatric state and fluctuation scores with STN low-frequency activity (4-12 Hz) was assessed. An acute low neuropsychiatric state in the OFF-medication condition was associated with elevated theta/low-alpha power. Moreover, the 6-8 Hz activity was indicative of the neuropsychiatric state change following medication intake. Those results were most evident in recordings from the ventral contacts closer to the limbic STN, while chronic stimulation settings covering the dorsal associative and motor STN captured a similar trend. STN low-frequency activity may serve as a biomarker for the acute neuropsychiatric state and neuropsychiatric responsiveness to dopamine and may inform future sensing-guided DBS strategies.

Identifiers

PMID41540043
PMCPMC12820131

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.