Evidence map›Paper›PMID 41540015›Full record

ArticleInternational journal of oral science2026

Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progression of oral squamous cell carcinoma through ABCA1-regulated cholesterol efflux.

Nan Ni, Moxu Wang, Zhiran Yuan, Leqi Zhang, Jilin Cai, Qingqing Du, Pengcheng Li, Chang Gao, Hanwen Zhang, Yuancheng Li and 1 more

Erratum issuedAbstract read
In one paragraph

Article in International journal of oral science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Nan Ni *Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Moxu Wang *Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Zhiran YuanJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Leqi ZhangJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Jilin CaiJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Qingqing DuJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Pengcheng LiJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Chang GaoJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Hanwen ZhangJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Yuancheng LiCentral Research Laboratory, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology, Chinese Academy of Medicine Sciences and Peking Union Medical College, Nanjing, China.
Hua YuanJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China. yuanhua@njmu.edu.cn.ORCID 0000-0002-5855-2196

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81672678
6 · The paper itself

Abstract

Splice quantitative trait loci (sQTL) serve as another critical link between genetic variations and human diseases, besides expression quantitative trait loci (eQTL). Their role in oral squamous cell carcinoma (OSCC) development remains unexplored. We collected surgically resected cancer and adjacent normal epithelial tissue samples from 67 OSCC cases, and extracted RNA for sequencing after quality control. A genome-wide sQTL analysis was performed using the RNA sequencing data from 67 normal oral epithelial tissue samples. We included peripheral blood DNA samples from 1044 patients with OSCC and 3199 healthy controls to conduct a genome-wide association study. Systematic screening of sQTLs associated with OSCC risk identified a sQTL variant-the rs737540-T allele-independent of eQTLs, significantly associated with an increased risk of OSCC (OR = 1.2, P = 6.84 × 10

Indexed as

ATP Binding Cassette Transporter 1Carcinoma, Squamous CellCholesterolDNA-Binding ProteinsErbB ReceptorsMouth NeoplasmsOligonucleotides, AntisenseAlternative SplicingDisease ProgressionFemaleGenome-Wide Association StudyHumansMaleMiddle AgedQuantitative Trait LociABCA1 protein, humanATP Binding Cassette Transporter 1CholesterolDNA-Binding ProteinsEGFR protein, humanErbB ReceptorsOligonucleotides, Antisense

Identifiers

PMID41540015
PMCPMC12808199

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.