Evidence map›Paper›PMID 41540008›Full record

ArticleNature communications2026

Inactive ryanodine receptors sustain lysosomal availability for autophagy by promoting ER-lysosomal contact site formation.

Tim Vervliet, Jens Loncke, Marko Sever, Karan Ahuja, Chris Van den Haute, Tomas Luyten, Grace E Stutzmann, Catherine Verfaillie, Tihomir Tomašič, Geert Bultynck

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Mitochondria-Targeting Moieties Based on N-Tethered Pyridinium Cations.Angewandte Chemie (International ed. in English) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tim VervlietLaboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, KU Leuven, 3000, Leuven, Belgium. tim.vervliet@kuleuven.be.ORCID http://orcid.org/0000-0002-4030-5875
Jens LonckeLaboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, KU Leuven, 3000, Leuven, Belgium.
Marko SeverFaculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia.
Karan AhujaDepartment of Development and Regeneration, Stem Cell Institute, KU Leuven, 3000, Leuven, Belgium.
Chris Van den HauteResearch group for Neurobiology and Gene Therapy, Department of Neuroscience and Leuven Viral Vector Core, KU Leuven, 3000, Leuven, Belgium.
Tomas LuytenLaboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, KU Leuven, 3000, Leuven, Belgium.ORCID http://orcid.org/0000-0003-2028-818X
Grace E StutzmannCenter for Neurodegenerative Disease and Therapeutics, Rosalind Franklin University of Medicine and Science, Chicago, IL, USA.
Catherine VerfaillieDepartment of Development and Regeneration, Stem Cell Institute, KU Leuven, 3000, Leuven, Belgium.ORCID http://orcid.org/0000-0001-7564-4079
Tihomir TomašičFaculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia.ORCID http://orcid.org/0000-0001-5534-209X
Geert BultynckLaboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, KU Leuven, 3000, Leuven, Belgium. geert.bultynck@kuleuven.be.ORCID http://orcid.org/0000-0002-5968-4828

Funding

Intracellular organelle deficits driving Alzheimer's diseaseR01AG065628 · NIA · ROSALIND FRANKLIN UNIV OF MEDICINE & SCI · PI SEKLER, ISRAEL, STUTZMANN, GRACE E. · 2024 to 2024
$431k
Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders) 12ZG121NFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) 209833/1S03424NFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) FWO-SBO-S001221N-OrganIDFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) G081821NNIA NIH HHS R01 AG065628The Slovenian Research and Innovation Agency (ARIS) P1-0208
6 · The paper itself

Abstract

Lysosomal and endoplasmic reticulum (ER) Ca

Indexed as

AutophagyEndoplasmic ReticulumLysosomesRyanodine Receptor Calcium Release ChannelVacuolar Proton-Translocating ATPasesAnimalsCalciumExocytosisHumansCalciumRyanodine Receptor Calcium Release ChannelVacuolar Proton-Translocating ATPases

Identifiers

PMID41540008
PMCPMC12868791

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.