Evidence map›Paper›PMID 41539682›Full record

ArticleZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences2026

[Comparison of functional outcomes between tenecteplase and alteplase as bridging thrombolysis prior to mechanical throm-bectomy for acute ischemic stroke patients with large vessel occlusion].

Zhenghao Shi, Jiansheng Yang, Zhenchan Lu, Yaojie Cai, Yi Zhu, Gongchun Huang, Hui Zhu, Min Lou, Jianhua Cheng

Registry-linked trialAbstract readComparative StudyEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04487340 (Computer-based Online Database of Acute Stroke Patients for Stroke Management Quality Evaluation), which is not on this map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04487340 recruitingnot on this map

Computer-based Online Database of Acute Stroke Patients for Stroke Management Quality Evaluation

Typeobservational_patient_registrySponsorSecond Affiliated Hospital, Zhejiang University, School of MedicineRan2016 to 2028Enrolled200,000ConditionsStroke, AcuteArmsEducation
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Zhenghao ShiDepartment of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China. kongke@zju.edu.cn.
Jiansheng YangDepartment of Neurology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. yangjiansheng@zju.edu.cn.
Zhenchan LuDepartment of Neurology, Huzhou Central Hospital, Huzhou 313000, Zhejiang Province, China.
Yaojie CaiDepartment of Neurology, Zhuji People's Hospital, Shaoxing 311800, Zhejiang Province, China.
Yi ZhuDepart-ment of Neurology, Ningbo Medical Center Lihuili Hospital, Ningbo 315000, Zhejiang Province, China.
Gongchun HuangDepartment of Neurology, the First People's Hospital of Pinghu, Jiaxing 314200, Zhejiang Province, China.
Hui ZhuDepartment of Neurology, Changxing County People's Hospital, Huzhou 313100, Zhejiang Province, China.
Min LouDepartment of Neurology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Jianhua ChengDepartment of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China. chengjianhua@wmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo compare the efficacy and safety of tenecteplase versus alteplase as bridging intravenous thrombolysis before mechanical thrombectomy in acute ischemic stroke (AIS) patients with large vessel occlusion.

methodsIn this retrospective cohort study, data were extracted from the Acute Stroke Patients for Stroke Management Quality Evaluation online database (CASE-Ⅱ, NCT04487340). Patients with AIS and large vessel occlusion who received tenecteplase or alteplase followed by mechanical thrombectomy within 24 hours of symptom onset from December 2022 to March 2025 were included. The patients were divided into the tenecteplase group and the alteplase group. Propensity score matching (1∶4) was performed based on age, sex, door-to-needle time (DNT), door-to-puncture time (DPT), and onset-to-door time. Binary logistic regression and general linear models were used to compare 3-month functional and safety outcomes. Sensitivity analysis was conducted for patients with onset-to-needle time (ONT)≤4.5 h, and subgroup analyses were performed based on age, sex, baseline National Institutes of Health Stroke Scale (NIHSS) score, occlusion site, DNT and DPT.

resultsAmong 1505 enrolled patients, 250 received tenecteplase and 1255 received alteplase. No significant differences were observed in 3-month functional outcomes between the two groups (all

conclusionsIn AIS patients with large vessel occlusion undergoing bridging thrombolysis before mechanical thrombectomy, tenecteplase and alteplase showed comparable 3-month functional and safety outcomes.

Indexed as

Ischemic StrokeTenecteplaseThrombolytic TherapyTissue Plasminogen ActivatorAgedFemaleFibrinolytic AgentsHumansMaleMiddle AgedObservational Studies as TopicRetrospective StudiesThrombectomyTreatment OutcomeFibrinolytic AgentsTenecteplaseTissue Plasminogen ActivatorAcute ischemic strokeAlteplaseClinical outcomeLarge vessel occlusionMechanical thrombectomyRetrospective studySafetyTenecteplase

Identifiers

PMID41539682
PMCPMC12980118

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