Evidence map›Paper›PMID 41539600›Full record

ArticleJournal of advanced research2026

Phocaeicola vulgatus promote growth rate via tryptophan metabolism pathway mediated gut sIgA production in Taihe Silky fowl.

Wentao Li, Haoneng Guo, Qi Wang, Dapeng Peng, Yizhen Wang, Zeqing Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wentao LiNational Engineering Research Centre for Green Feed and Healthy Farming, Zhejiang University, Hangzhou, Zhejiang 310000, China; Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Hangzhou, Zhejiang 310000, China; Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Hangzhou, Zhejiang 310000, China; Zhejiang Key Laboratory of Nutrition and Breeding for High-quality Animal Products, Zhejiang University, Hangzhou, Zhejiang 310000, China.
Haoneng GuoNational Engineering Research Centre for Green Feed and Healthy Farming, Zhejiang University, Hangzhou, Zhejiang 310000, China; Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Hangzhou, Zhejiang 310000, China; Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Hangzhou, Zhejiang 310000, China; Zhejiang Key Laboratory of Nutrition and Breeding for High-quality Animal Products, Zhejiang University, Hangzhou, Zhejiang 310000, China.
Qi WangNational Engineering Research Centre for Green Feed and Healthy Farming, Zhejiang University, Hangzhou, Zhejiang 310000, China; Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Hangzhou, Zhejiang 310000, China; Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Hangzhou, Zhejiang 310000, China; Zhejiang Key Laboratory of Nutrition and Breeding for High-quality Animal Products, Zhejiang University, Hangzhou, Zhejiang 310000, China.
Dapeng PengZhejiang Provincial Engineering Research Center of Animal Biological Products, Center for Veterinary Sciences, Zhejiang University, Hangzhou, Zhejiang 310000, China.
Yizhen WangNational Engineering Research Centre for Green Feed and Healthy Farming, Zhejiang University, Hangzhou, Zhejiang 310000, China; Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Hangzhou, Zhejiang 310000, China; Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Hangzhou, Zhejiang 310000, China; Zhejiang Key Laboratory of Nutrition and Breeding for High-quality Animal Products, Zhejiang University, Hangzhou, Zhejiang 310000, China.
Zeqing LuNational Engineering Research Centre for Green Feed and Healthy Farming, Zhejiang University, Hangzhou, Zhejiang 310000, China; Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Hangzhou, Zhejiang 310000, China; Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Hangzhou, Zhejiang 310000, China; Zhejiang Key Laboratory of Nutrition and Breeding for High-quality Animal Products, Zhejiang University, Hangzhou, Zhejiang 310000, China. Electronic address: zqlu2012@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTaihe Silky Fowl (TSF) has a long growth cycle and slow growth rate, how to effectively improve the growth rate of TSF has become the primary concern for breeders. Currently, extensive research has established the gut microbiota's role in modulating growth rate of commercial chicken breeds, while the specific microbial mechanisms influencing TSF growth rate remain poorly understood.

objectivesTherefore, this study aimed to identify growth rate-associated key microbial species in TSF through multi-omics approaches, experimentally validate their growth-promoting roles via controlled interventions, and elucidate the species-metabolite-host interaction mechanisms.

methodsCecal metagenome and metabolome was used to search for differential key microbiota and metabolites of TSF with different growth rate, the whole genome of key microbiota was used to identify the relationship between microbiota and metabolites, and gavage key microbiota to TSF was used to demonstrate the effectiveness of probiotics and preliminarily explore their mechanisms of action.

resultsCecal metagenome analysis demonstrated a significant enrichment of Phocaeicola vulgatus (P. vulgatus) in high-growth-rate fowls, Erysipelotrichaceae bacterium was significantly enriched in low-growth-rate fowls. The differential metabolites between the two groups were significantly enriched in tryptophan metabolism pathway. Subsequently, gene analysis revealed that P. vulgatus encoded tryptophan biosynthesis genes. In feeding experiment, oral gavage P. vulgatus improved the TSF final body weight, average growth rate and average daily gain, increased cecal P. vulgatus abundance, enriched the metabolites in tryptophan metabolism pathway both in the cecum and serum, and upregulated cecal tissue gene expression in the 'intestinal immune network for IgA production' pathway resulting in the higher secretory IgA (sIgA) concentrations in cecal tissue and luminal content than the control group.

conclusionP. vulgatus promoted the growth rate of TSF by optimizing the cecal microbiota, elevating cecal tryptophan metabolites and stimulating sIgA production via sIgA gene upregulation in cecal tissues, thereby enhancing host immune modulation. These findings elucidated the microbiota-metabolite-host axis governing TSF growth regulation, providing both mechanistic insights and practical applications for probiotic-based strategies to enhance growth performance and gut health in this valuable poultry breed.

Indexed as

ChickensGastrointestinal MicrobiomeImmunoglobulin A, SecretoryTryptophanAnimalsCecumMetagenomeProbioticsImmunoglobulin A, SecretoryTryptophanGrowth ratePhocaeicola vulgatussIgATaihe Silky fowlTryptophan metabolism

Identifiers

PMID41539600
PMCPMC13669582

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.