SynthesisBiological psychiatry2026
Genomic Studies of Suicidal Thoughts and Behaviors in Latin American Populations: A Systematic Review.
Synthesis in Biological psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors.
Funding
Abstract
backgroundSuicide is a leading cause of death globally, with disproportionately rising rates in Latin America. Despite increasing global interest in the biology of suicidal behavior, Latin American and Hispanic/Latinx populations remain underrepresented in genomic research. In this systematic review, we synthesized current evidence on genomic studies of suicidality in these populations.
methodsWe reviewed molecular studies of suicidal ideation, suicide attempt, nonsuicidal self-injury, or suicide death among Latin American or Hispanic/Latinx individuals (PROSPERO registration: CRD42023416616). Eligible studies examined family risk, genetic, epigenetic, or transcriptomic markers. Searches were conducted in PubMed, SciELO, REDALyC, and regional journals. Synthesis used a narrative approach and random-effects meta-analyses when feasible. Risk of bias was assessed using the Newcastle-Ottawa Scale and the Q-Genie tool. A coauthorship network analysis was performed to characterize collaboration patterns.
resultsFifty-nine studies met inclusion criteria: 3 family, 50 genetic, 6 transcriptomic, and 3 epigenetic studies (categories not mutually exclusive). Candidate gene studies mainly examined serotonergic and stress-response pathways but yielded inconsistent results. Meta-analyses for TPH1 (rs1800532), HTR2A rs6313 (T102C), and 5-HTTLPR (rs25531) showed no significant associations. Recent genome-wide and polygenic score studies identified ancestry-specific loci, although small samples and limited functional annotation resources hindered follow-up. Transcriptomic and epigenetic studies have implicated neurodevelopmental and immune-related processes. Collaboration networks were dominated by a single hub, with limited cross-group integration.
conclusionsGenomic research on suicidality in Latin America is growing but remains fragmented and underpowered. Increasing representative sampling, implementing ancestry-aware methods, and fostering collaborations are essential to advance research and inform prevention strategies in these populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.