ArticleJournal of the American Chemical Society2026
Engineered Flavin-Dependent Halogenases Catalyze C-C Bond Formation via Enantioselective Semipinacol Rearrangement.
Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Alternating-Polarity Electrolysis Enables Efficient Enantioselective Semipinacol Rearrangement Using Sodium Chloride.Journal of the American Chemical Society · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
The semipinacol rearrangement comprises a valuable class of synthetic organic transformations that provide access to useful molecular scaffolds via C-C bond cleavage and formation. Naturally occurring semipinacolases have thus far been limited to examples in alkaloid or polyketide biosynthesis, and the only new-to-nature semipinacolase was reported based on Brønsted acid catalysis with limited substrate scope. Herein, we report that flavin-dependent halogenases (FDHs) can catalyze enantioselective halogenative semipinacol rearrangement of prochiral allylic alcohols. This biocatalytic platform exhibits a broad substrate scope, affording chiral ketones bearing quaternary stereocenters with a high enantioselectivity. The reaction system displays a
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