Evidence map›Paper›PMID 41538719›Full record

ArticleJournal of natural products2026

Mechanistic Studies of the Calcium-Dependent Antibiotics via Cofactor Engineering.

Shao-Lun Chiou, Yu-Chi Chang, Ya-Rong Chen, Thomas Ma, John Chu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of natural products, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shao-Lun ChiouDepartment of Chemistry, National Taiwan University, No. 1 Section 4, Roosevelt Road, Taipei 10617, Taiwan.ORCID 0009-0003-5502-4966
Yu-Chi ChangDepartment of Chemistry, National Taiwan University, No. 1 Section 4, Roosevelt Road, Taipei 10617, Taiwan.
Ya-Rong ChenDepartment of Chemistry, National Taiwan University, No. 1 Section 4, Roosevelt Road, Taipei 10617, Taiwan.
Thomas MaDepartment of Chemistry, National Taiwan University, No. 1 Section 4, Roosevelt Road, Taipei 10617, Taiwan.
John ChuDepartment of Chemistry, National Taiwan University, No. 1 Section 4, Roosevelt Road, Taipei 10617, Taiwan.ORCID 0000-0002-7033-7229

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The defining feature of calcium-dependent antibiotics (CDAs) is that they require the presence of calcium cation (Ca(II)) as a cofactor to exert antibacterial activity. We recently showed that substituting two key aspartic acids (Asp) with serine (Ser) in laspartomycin C (LspC) converts it from a CDA into a boron-dependent antibiotic (BDA). This synthetic analog (termed

Indexed as

Anti-Bacterial AgentsCalciumAspartic AcidBoronic AcidsDaptomycinMicrobial Sensitivity TestsMolecular StructureAnti-Bacterial AgentsAspartic Acidbenzeneboronic acidBoronic AcidsCalciumDaptomycin

Identifiers

PMID41538719
PMCPMC12954748

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.