Evidence map›Paper›PMID 41538419›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Magnetic Resonance Imaging Reveals Meningeal Lymphatic Impairment in Lung Adenocarcinoma Brain Metastasis Progression.

Yuan Zhang, Shucheng Jin, Penghui Guo, Yuying Yin, Yichun Hua, Xiaosheng Ding, Zhe Zhang, Shuo Chen, Xu Han, Baowang Li and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yuan ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0003-0543-5022
Shucheng JinDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Penghui GuoDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yuying YinClinical Trial Research Center, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Yichun HuaDepartment of Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xiaosheng DingDepartment of Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Zhe ZhangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Shuo ChenShanghai United Imaging Healthcare Co., Ltd, Shanghai, China.
Xu HanWuhan United Imaging Life Science Instrument Co., Ltd, Wuhan, China.
Baowang LiDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yan LiuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xiaoyan LiClinical Trial Research Center, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Deling LiDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jing JingDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Wei ShiBeijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Wang JiaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-0992-6702

Funding

Beijing Postdoctoral Research FoundationChina Postdoctoral Science Foundation GZC20241103National Key Research and Development Program of China 2022YFC2405300
6 · The paper itself

Abstract

Meningeal lymphatic vessels (mLVs) contribute to brain immune surveillance; however, their structural and functional alterations in brain metastasis remain incompletely defined. Here, we optimized a magnetic resonance imaging protocol to quantitatively analyze mLV structure and drainage function. Using murine lung adenocarcinoma brain metastasis models and clinical imaging data, we reveal significant mLV disruption surrounding the superior sagittal sinus (SSS), which results in impaired drainage to deep cervical lymph nodes (dCLNs). Among ten cervical lymph-node levels assessed clinically, level IIA lymph nodes most accurately reflect mLV drainage efficiency. Functionally, mLV ablation compromised intrathecal chemotherapy efficacy in mice, while clinically, greater mLV structural and functional impairment correlates with disease progression in lung adenocarcinoma brain metastasis. Collectively, our findings demonstrate that lung adenocarcinoma brain metastases disrupt SSS-adjacent mLVs (mLVs-SSS), which potentially facilitates metastatic progression through compromised immune surveillance.

Indexed as

Adenocarcinoma of LungBrain NeoplasmsLung NeoplasmsLymphatic VesselsMagnetic Resonance ImagingMeningesAnimalsDisease Models, AnimalDisease ProgressionFemaleHumansLymphatic MetastasisLymph NodesMaleMicebrain metastasiscervical lymph nodesdisease progressionmeningeal lymphatic vesselsMRI

Identifiers

PMID41538419
PMCPMC13042558

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.