Evidence map›Paper›PMID 41538100›Full record

ArticleClinical oral investigations2026

Lymph node metastasis pattern in recurrent and ipsilateral second primary oral squamous cell carcinoma.

Yijing Cai, Maged Ali Al-Aroomi, Jie Chen, Saiwen Song, Jie Wang, Canhua Jiang

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Article in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Yijing CaiDepartment of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Maged Ali Al-AroomiDepartment of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Jie ChenDepartment of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Saiwen SongDepartment of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Jie WangXiangya School of Basic Medicine, Central South University, Changsha, Hunan Province, China. wj0988@csu.edu.cn.
Canhua JiangDepartment of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China. canhuaj@csu.edu.cn.

Funding

High-level Talent Plan of Hunan Provincial Health Commission 2023018Key R&D Program of Hunan Province 2022SK2048Major Project of Natural Science Foundation of Hunan Province 2021JC0002National Natural Science Foundation of China 82103473
6 · The paper itself

Abstract

objectiveTo examine the patterns of lymph node metastasis and associated risk factors in patients with recurrent tumors or ipsilateral second primary tumors (SPT), with the goal of providing insights for clinical diagnosis and management.

methodsA retrospective analysis was conducted on patients who underwent radical surgery for oral squamous cell carcinoma (OSCC) and experienced tumor recurrence or ipsilateral SPT between January 2017 and March 2023. Comprehensive clinical and pathological data were collected at both the time of initial treatment and recurrent or ipsilateral SPT.

resultsMost common primary OSCC sites were the tongue and buccal mucosa, while recurrent and ipsilateral SPT primarily occurred in the buccal mucosa. The lymph node metastasis rate for primary OSCC was 22.9%, increasing to 42.2% in recurrent and ipsilateral SPT (p < 0.001). Primary OSCC tended to metastasize to levels I-III, while recurrent and ipsilateral SPT more commonly metastasized to ipsilateral level V and contralateral level I. Multivariate logistic regression showed moderately and poorly tumor differentiation and T2 stage were significant risk factors for lymph node metastasis in primary OSCC. In recurrent and ipsilateral SPT, poorly differentiated tumors and T2 stage were similarly associated with increased lymph node metastasis. Both lymph node and distant metastases were significant prognostic risk factors in recurrent or ipsilateral SPT.

conclusionRecurrent and ipsilateral SPT exhibit a higher likelihood of lymph node metastasis compared to primary OSCC, particularly to ipsilateral level V and contralateral level I lymph nodes. This pattern of metastasis is strongly associated with a poorer prognosis.

Indexed as

Carcinoma, Squamous CellLymphatic MetastasisMouth NeoplasmsNeoplasm Recurrence, LocalNeoplasms, Second PrimaryAdultAgedFemaleHumansMaleMiddle AgedNeoplasm StagingPrognosisRetrospective StudiesRisk FactorsIpsilateral second primary tumorLymphatic metastasisOral squamous cell carcinomasRecurrenceRisk factors

Identifiers

PMID41538100

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