Mechanistic Insights Into the Anti-Obesity Effects of Gondoic Acid: Regulation of AMPK Signalling and Obesity Related Gene Expression in Obese Mice.

Considered one of the most prevalent monounsaturated fatty acids (MUFA) from marine and plant sources, omega-9 fatty acids (n-9) have gained worldwide recognition since due to its strong anti-obesogenic properties. These findings highlight the anti-obesity efficacy and mechanism of n-9, gondoic acid (GA) for anti-obesity interventions, offering a novel research perspective at recent research field. The animals (BALB/c male mice) were segregated into six study groups: the control group (C) received normal chow diet; the vehicle control group (VC) received normal chow diet + olive oil; high fat diet (HFD) received by the obese control group (OC); and the treatment-I (T-I), treatment-II (T-II), treatment-III (T-III) group co-administered with GA as follows: 1 mg/kg GA + HFD; 2 mg/kg GA + HFD; 4 mg/kg GA + HFD. In this study, GA was delivered orally once daily for six weeks to diet-induced obese mice. According to the findings, administering GA decreased weight gain, blood lipid profile levels, improved inflammation and adipogenesis. The mRNA expression studies and western blot assay found that GA administration may boost glucose metabolism, enhance the process of thermogenesis and β-oxidation in mitochondria via the AMPK mechanism, reducing HFD-induced adiposity. In brief, our findings can point in a broader direction for the use of GA in obesity based on genetic indicators.