Evidence map›Paper›PMID 41538058›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Design, synthesis and biological profiling of bis-thiazole linked Schiff bases as effective enzyme inhibitors for targeting urease and thymidine phosphorylase proteins.

Yousaf Khan, Hina Sarfraz, Mahrukh Naseem, Rubina Adnan, Syeda Farwa Naqvi, Azmatullah Khan, Urooba Gulshan, Syed Aminullah

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yousaf KhanDepartment of Chemistry, COMSATS University Islamabad, Islamabad, 45550, Pakistan. yousaf7n@gmail.com.
Hina SarfrazDepartment of Chemistry, Quaid-I-Azam University Islamabad, Islamabad, 45320, Pakistan.
Mahrukh NaseemDepartment of Zoology, University of Balochistan, Quetta, Pakistan.
Rubina AdnanDepartment of Computer Science, COMSATS University Islamabad, Islamabad, 45550, Pakistan.
Syeda Farwa NaqviDepartment of Zoology, Quaid-I-Azam University Islamabad, Islamabad, 45320, Pakistan.
Azmatullah KhanDepartment of Zoology, Quaid-I-Azam University Islamabad, Islamabad, 45320, Pakistan.
Urooba GulshanDepartment of Chemistry, COMSATS University Islamabad, Islamabad, 45550, Pakistan.
Syed AminullahDepartment of Chemistry, COMSATS University Islamabad, Islamabad, 45550, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Earlier therapeutic strategies primarily focused on combating diseases caused by external pathogens; recent advancements have highlighted the pivotal role of endogenous enzymes in the progression of non-infectious disorders. Enzymes such as urease  and thymidine phosphorylase   have been implicated in various pathological conditions, prompting the need for effective enzyme-targeted inhibitors. In this study, a novel series of bis-thiazole linked linked Schiff Bases  (1-10) was designed and synthesized as potential dual enzyme inhibitors. The structural integrity of the synthesized compounds was confirmed by FTIR,

Indexed as

Drug DesignEnzyme InhibitorsThiazolesThymidine PhosphorylaseUreaseHumansMolecular Docking SimulationSchiff BasesStructure-Activity RelationshipEnzyme InhibitorsSchiff BasesThiazolesThymidine PhosphorylaseUreaseHelicobacter pyloriHuman thymidine phosphorylaseMolecular dockingProteus mirabilisSARSchiff BaseThiazoleUrease

Identifiers

PMID41538058

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.