ArticleAnalytical chemistry2026
Encapsulation of mRNA in Therapeutics Like Lipid Nanoparticles Probed by Deep-UV Resonance Raman Spectroscopy.
Article in Analytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma-Brain Organoid Interfaces.Advanced healthcare materials · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Messenger RNA (mRNA) therapeutics have emerged as a powerful platform for treating a wide range of diseases, but their clinical success depends on overcoming the issues of instability and delivery. mRNAs are typically unstable and require encapsulation in lipid nanoparticles (LNPs) for efficient delivery. This study quantifies free and encapsulated mRNAs within LNPs in a model vaccine using deep-UV resonance Raman (DUVRR) spectroscopy. DUVRR spectroscopy with excitation at 266 nm, matching the maximum UV absorption of mRNA, enables spectral differentiation of mRNA based on its degree of encapsulation─from fully encapsulated to partially exposed to completely free. Raman spectra were acquired from the samples with progressively decreasing lipid concentrations while maintaining a fixed mRNA concentration; vibrational modes associated with mRNA-lipid interactions were identified. Principal component analysis (PCA) revealed spectral variations linked to the lipid presence, especially between 1270 and 1800 cm
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.