Evidence map›Paper›PMID 41537432›Full record

ArticleeLife2026

Functionally coupled ion channels begin co-assembling at the start of their synthesis.

Roya Pournejati, Jessica M Huang, Michael Ma, Claudia M Moreno, Oscar Vivas

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Roya PournejatiDepartment of Pharmacology, University of Washington, Seattle, United States.ORCID https://orcid.org/0000-0001-9290-4960
Jessica M HuangDepartment of Pharmacology, University of Washington, Seattle, United States.ORCID https://orcid.org/0009-0003-6452-3054
Michael MaDepartment of Pharmacology, University of Washington, Seattle, United States.
Claudia M MorenoDepartment of Neurobiology and Biophysics, University of Washington, Seattle, United States.ORCID https://orcid.org/0000-0001-8397-3649
Oscar VivasDepartment of Pharmacology, University of Washington, Seattle, United States.ORCID https://orcid.org/0000-0002-0964-385X

Funding

Mechanisms behind the clustering of BK and calcium channelsR35GM142690 · NIGMS · UNIVERSITY OF WASHINGTON · PI VIVAS, OSCAR · 2021 to 2025
$1.9M
Molecular mechanisms of mechanosensation in the cardiac pacemakerR01HL162609 · NHLBI · UNIVERSITY OF WASHINGTON · PI Claudia Marcela Moreno · 2022 to 2026
$1.9M
Howard Hughes Medical Institute Freeman HrabowskiNational Heart Lung and Blood Institute HL162609NHLBI NIH HHS R01 HL162609NIGMS NIH HHS R35 GM142690NIGMS NIH HHS R35GM142690
6 · The paper itself

Abstract

Calcium binding to BK channels lowers BK activation threshold, substantiating functional coupling with calcium-permeable channels. This coupling requires close proximity between different channel types, and the formation of BK-Ca

Indexed as

Calcium Channels, L-TypeLarge-Conductance Calcium-Activated Potassium ChannelsProtein BiosynthesisProtein MultimerizationAnimalsCalcium ChannelsCell MembraneEndoplasmic ReticulumGolgi ApparatusHumansProtein BindingRatsRNA, MessengerCacna1d protein, ratCalcium ChannelsCalcium Channels, L-TypeLarge-Conductance Calcium-Activated Potassium ChannelsRNA, MessengerBK channelcell biologyclusteringfunctional couplingmolecular biophysicsnonerat insulinoma cell linestructural biologystructural couplingvoltage-gated Ca channel

Identifiers

PMID41537432
PMCPMC12807452

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.