ArticleMolecular therapy. Oncology2026
Novel syngeneic model of anti-mouse CLDN18.2 CAR -T therapy for gastric cancer demonstrates a synergy with TGF-β and PD-L1 inhibitors.
Article in Molecular therapy. Oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
There are very few syngeneic mouse cell line models available for gastric cancer owing to the rarity of stomach epithelium-specific promoter. Mouse cell line models are useful to study an immunologically intact tumor microenvironment, especially in the setting of CAR-T studies that often use immunocompromised mice. To establish a mouse cell line faithfully recapitulating human gastric cancer, we generated the S6M cell line from an autochthonous gastric cancer formed in the stomach of a female mouse deficient in
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