ReviewiScience2026
Magnesium metabolism: A potential breakthrough in osteoporosis intervention.
Review in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Welding Techniques for Magnesium Alloy Joints: A Comprehensive Review.Materials (Basel, Switzerland) · 2026Review
- Using Magnesium and Magnesium-Based Alloys as a Novel Biomaterial to Create Medical Devices by AM Techniques-A Review.Materials (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis (OP), a multifactorial systemic skeletal disease, is characterized by significant reductions in bone density and quality, coupled with progressive deterioration of bone microarchitecture, and poses a significant health challenge. Conventional therapies, while partially effective, have limitations. Recent studies highlight the crucial role of magnesium (Mg) metabolism in bone health. Mg regulated bone homeostasis by promoting osteoblasts (OBs) differentiation and suppressing osteoclasts (OCs) activity. They also influence intracellular metabolism and hormonal functions. Mg deficiency can disrupt calcium (Ca) homeostasis, exacerbating bone resorption. Novel interventions, including Mg supplementation, Mg-based implants, offer promising approaches. This review synthesizes evidence on Mg's impact on OP pathogenesis and evaluates these therapeutic strategies, aiming to guide future research and clinical applications. It underscores Mg metabolic balance as a critical target for OP management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.