Evidence map›Paper›PMID 41536993›Full record

ArticleiScience2026

The encoding of interoceptive-based predictions by the paraventricular nucleus of the thalamus D2R+ neurons.

Briana Machen, Sierra N Miller, Al Xin, Carine Lampert, Lauren Assaf, Julia Tucker, Sarah Herrell, Francisco Pereira, Gabriel Loewinger, Sofia Beas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Briana MachenDepartment of Neurobiology, University of Alabama at Birmingham, University Boulevard, Birmingham, AL 35294, USA.
Sierra N MillerDepartment of Neurobiology, University of Alabama at Birmingham, University Boulevard, Birmingham, AL 35294, USA.
Al XinMachine Learning Team, National Institute of Mental Health, Convent Drive, Bethesda, MD 20892, USA.
Carine LampertDepartment of Neurobiology, University of Alabama at Birmingham, University Boulevard, Birmingham, AL 35294, USA.
Lauren AssafDepartment of Neurobiology, University of Alabama at Birmingham, University Boulevard, Birmingham, AL 35294, USA.
Julia TuckerDepartment of Neurobiology, University of Alabama at Birmingham, University Boulevard, Birmingham, AL 35294, USA.
Sarah HerrellDepartment of Neurobiology, University of Alabama at Birmingham, University Boulevard, Birmingham, AL 35294, USA.
Francisco PereiraMachine Learning Team, National Institute of Mental Health, Convent Drive, Bethesda, MD 20892, USA.
Gabriel LoewingerMachine Learning Team, National Institute of Mental Health, Convent Drive, Bethesda, MD 20892, USA.
Sofia BeasDepartment of Neurobiology, University of Alabama at Birmingham, University Boulevard, Birmingham, AL 35294, USA.

Funding

Mentored Experiences in Research, Instruction and Teaching (MERIT) Program - administrative supplementK12GM088010 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SCHNEIDER, DAVID ALAN · 2009 to 2024
$9.2M
Mapping Thalamo-striatal Neuronal Circuits Underlying Motivational DriveR00MH126429 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BEAS, SOFIA · 2022 to 2024
$796k
NIGMS NIH HHS K12 GM088010NIMH NIH HHS R00 MH126429
6 · The paper itself

Abstract

Interoceptive predictions are internal models that guide behavior by anticipating physiological needs based on past experiences and environmental cues. The paraventricular nucleus of the thalamus (PVT), which receives both interoceptive and exteroceptive inputs, is well-positioned to integrate these signals. Using fiber photometry and bulk calcium imaging in mice performing a reward-based linear maze task, we found that dopamine receptor 2-expressing PVT neurons (PVT

Indexed as

Biological sciences

Identifiers

PMID41536993
PMCPMC12796593

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.