Evidence map›Paper›PMID 41536991›Full record

ReviewiScience2026

Mitochondria as key targets underlying hypomagnetic field-induced biological effects.

Jie Ren, Menglin Wang, Chenchen Zhao, Yukai Luo, Lanxiang Tian

Abstract readReview
In one paragraph

Review in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Quantum Effects in Evolution: Terrestrial Fine-Tuning of Magnetic Parameters.Computational and structural biotechnology journal · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jie RenBiogeomagnetism Group, Key Laboratory of Planetary Science and Frontier Technology, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing, China.
Menglin WangBiogeomagnetism Group, Key Laboratory of Planetary Science and Frontier Technology, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing, China.
Chenchen ZhaoBiogeomagnetism Group, Key Laboratory of Planetary Science and Frontier Technology, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing, China.
Yukai LuoBiogeomagnetism Group, Key Laboratory of Planetary Science and Frontier Technology, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing, China.
Lanxiang TianBiogeomagnetism Group, Key Laboratory of Planetary Science and Frontier Technology, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the rapid development of human deep space exploration, prolonged exposure to hypomagnetic fields (HMF, <5 μT) - an environmental parameter with significantly reduced intensity compared to Earth's geomagnetic field (GMF) - poses unprecedented health challenges. Accumulating evidence demonstrates that HMF exposure induces negative effects on various system functions in animals, including the central nervous system, the cardiovascular system, and the musculoskeletal systems and so forth. In this review, we systematically summarize the multi-level impacts of HMF on mitochondrial quality control and function, proposing mitochondria as direct and sensitive targets of HMF, with iron-sulfur clusters potentially playing a pivotal role. We also explore possible HMF-regulated signaling pathways. In conclusion, this review provides a valuable foundation for understanding the cellular and molecular mechanisms of HMF's potential risks to astronauts and for developing future coping strategies during spaceflight.

Indexed as

Cellular physiologyFunctional aspects of cell biologySpace medicine

Identifiers

PMID41536991
PMCPMC12796539

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.