Evidence map›Paper›PMID 41536910›Full record

ArticleOpen respiratory archives

Innovative Approach to Early Lung Cancer Detection: Integrating a Comprehensive Screening Program and an Incidental Pulmonary Nodule Clinic.

Anna Sánchez-Cucó, Sally Santisteve, Anna Vila, Carlos Manzano, Maria Zuil, Aida Monge, Clara Sanz, Esther Gracia-Lavedan, Nerea Ramírez-Seco, Marcela Suárez and 23 more

Abstract read
In one paragraph

Article in Open respiratory archives. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Anna Sánchez-CucóTranslational Research in Respiratory Medicine, IRBLleida, Pulmonology Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
Sally SantisteveTranslational Research in Respiratory Medicine, IRBLleida, Pulmonology Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
Anna VilaTranslational Research in Respiratory Medicine, IRBLleida, Pulmonology Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
Carlos ManzanoTranslational Research in Respiratory Medicine, IRBLleida, Pulmonology Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
Maria ZuilTranslational Research in Respiratory Medicine, IRBLleida, Pulmonology Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
Aida MongeTranslational Research in Respiratory Medicine, IRBLleida, Pulmonology Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
Clara SanzTranslational Research in Respiratory Medicine, IRBLleida, Pulmonology Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
Esther Gracia-LavedanTranslational Research in Respiratory Medicine, IRBLleida, Pulmonology Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
Nerea Ramírez-SecoTranslational Research in Respiratory Medicine, IRBLleida, Pulmonology Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
Marcela SuárezTranslational Research in Respiratory Medicine, IRBLleida, Pulmonology Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
Silvia BarrilTranslational Research in Respiratory Medicine, IRBLleida, Pulmonology Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
Wassim El ArfaouiTranslational Research in Respiratory Medicine, IRBLleida, Pulmonology Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
Ivan D BenítezTranslational Research in Respiratory Medicine, IRBLleida, Pulmonology Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
Sonia GatiusPathology Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
Carlos A RomboláThoracic Surgery Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
Leandre FernándezRadiology Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
Marina PardinaRadiology Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
Maria Teresa EsquéRadiology Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
Virginia GarciaRadiotherapy Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
José David GonzálezRadiotherapy Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
Cora Andrea SampedroThoracic Surgery Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
Mario MontesinosThoracic Surgery Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
Juan Diego AvilesThoracic Surgery Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
Alberto RodrigoMedical Oncology Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
Jacinto AbellanedaPrimary Care Unit Rural 2 (South), Lleida, Spain.
Pere FarréPrimary Care Unit la Granadella, Lleida, Spain.
Lidia ViloPrimary Care Unit Rural 2 (South), Lleida, Spain.
David de Gonzalo-CalvoTranslational Research in Respiratory Medicine, IRBLleida, Pulmonology Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
Rowena YipMount Sinai School of Medicine, Department of Diagnostic, Molecular, and Interventional Radiology, NY, USA.
David F YankelevitzMount Sinai School of Medicine, Department of Diagnostic, Molecular, and Interventional Radiology, NY, USA.
Claudia I HenschkeMount Sinai School of Medicine, Department of Diagnostic, Molecular, and Interventional Radiology, NY, USA.
Ferran BarbéTranslational Research in Respiratory Medicine, IRBLleida, Pulmonology Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.
Jessica GonzálezTranslational Research in Respiratory Medicine, IRBLleida, Pulmonology Department, Arnau de Vilanova and Santa Maria University Hospital, Lleida, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Lung cancer (LC) is the leading cause of cancer-related death. Early detection strategies include LC screening (LCS) with low-dose computed tomography (LDCT) and incidental pulmonary nodule clinics (IPNCs). This study describes the structure, workflow, and outcomes of an integrated early diagnosis strategy combining LCS and IPNCs. Material and methods: We conducted a descriptive analysis of a prospective observational study (May 2023-June 2025) implementing an integrated IPNC-LCS model. All IPNC patients underwent initial LC-risk assessment: highly suspicious lesions were referred to a fast-track diagnostic pathway, low-risk patients to primary care (PC), and high-risk individuals to the LCS program. Additional referrals to the LCS program were received from pulmonology clinics and PC. The LCS program followed the I-ELCAP protocol, including LDCT, lung function testing, α1-antitrypsin deficiency (AATD) screening, and smoking cessation support. Results: The IPNC evaluated 481 individuals: 30 (6.2%) had suspicious lung lesions, with four stage I LC confirmed; 282 (58.6%) were classified as low-risk; and 150 (31.2%) as high risk of whom 97 were enrolled in LCS. The LCS program also received 199 referrals from PC and 122 from pulmonology clinics, totaling 418 participants at baseline (63.2% male; mean age 63.0 ± 6.43 years; 52.9% former smokers; 39.7% with COPD; 67.9% with emphysema). New diagnoses included emphysema ( Conclusions: This integrated IPNC-LCS model achieved high early-stage LC detection and enabled curative treatment, while uncovering unrecognized respiratory comorbidities and promoting smoking cessation.

Indexed as

Chronic obstructive pulmonary diseaseEarly-stage lung cancerEmphysemaLow-dose computed tomographyLung cancer screeningPulmonary nodule

Identifiers

PMID41536910
PMCPMC12796536

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.