Evidence map›Paper›PMID 41536850›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

Effect of antipsychotic medication use and type on mortality and cardiovascular risks in nursing home patients with dementia.

Hamid R Okhravi, Fang Fang, Melissa P Hunter, Brynn E Sheehan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hamid R OkhraviGlennan Center for Geriatrics and Gerontology Lawrence J. Goldrich Institute for Integrated NeuroHealth Macon and Joan Brock Virginia Health Sciences at Old Dominion University Norfolk Virginia USA.ORCID https://orcid.org/0009-0006-3684-5357
Fang FangDepartment of Medicine Research and Infrastructure Service Enterprise (RISE) Macon and Joan Brock Virginia Health Sciences at Old Dominion University Norfolk Virginia USA.
Melissa P HunterSentara Medical Group Neurology Division Macon and Joan Brock Virginia Health Sciences at Old Dominion University Norfolk Virginia USA.
Brynn E SheehanDepartment of Psychiatry and Behavioral Sciences Research & Infrastructure Service Enterprise (RISE) Macon and Joan Brock Virginia Health Sciences at Old Dominion University Norfolk Virginia USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Antipsychotic medication (APM) use in nursing home (NH) patients with dementia is common but carries risks. This study assessed the association between APM use and mortality, stroke, and myocardial infarction (MI) compared to non-use, as well as differences between first- and second-generation APMs. Methods: A serial cross-sectional study using Medicare data examined outcomes from 2012 to 2015 in a national sample of 328,138 US NH residents aged 50 and older with dementia. Multivariate logistic regressions were used to analyze risk. Results: APM use was associated with increased mortality in all years (odds ratio [OR] range: 2.39 to 1.23, all Discussion: Findings highlight the need for cautious APM use in dementia patients in NHs due to elevated mortality and stroke risks. Highlights: Study provides insights into APM risks in underrepresented nursing home (NH) dementia population.APM use in NH dementia patients is linked to higher death risk.First-generation APMs showed higher mortality risk than second-generation APMs.Overall, APM use is associated with increased stroke risk.No association was found between APM use and MI risk overall.

Indexed as

agitationAlzheimer's diseaseantipsychotic medicationsatypical antipsychoticsdementiafirst‐generation antipsychoticslong‐term careMedicare datamortalitymyocardial infarctionneuropsychiatric symptomsnursing homespsychotropic medicationssecond‐generation antipsychoticsstroke

Identifiers

PMID41536850
PMCPMC12795781

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.