ArticleFrontiers in cell and developmental biology2025
Fibroblast growth factor 9 activates fibroblast activation and drives the progress of shoulder stiffness.
Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Shoulder stiffness (SS) is a common disease that causes pain and restricted range of motion (ROM), involving synovial inflammation and joint capsule fibrosis. The specific pathogenesis of SS remains unclear. This study aimed to delineate the key molecular driving capsule fibrosis in SS. Methods: Joint capsule samples from SS and non-SS patients were collected, and high-throughput RNA sequencing along with bioinformatic analysis were performed. A mouse SS model was established via joint immobilization. Functional and immunofluorescence assay were conducted on NIH3T3s. LY294002 was used both in NIH3T3s and mouse SS models. Results: Transcriptomic analysis identified 100 differentially expressed genes (DEGs). Among the top hub genes, FGF9 was notably upregulated in the SS capsules. Conclusion: Our findings revealed that FGF9 drove fibroblast activation and joint capsule fibrosis in SS via the PI3K/Akt signaling pathway. Targeted inhibition of the PI3K/Akt signaling might represent a promising therapeutic strategy for SS.
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