ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2025
[Underlying Mechanism of the circ_0011462/miRNA-1200/SP1 Axis in Regulating Inflammatory Response, Apoptosis, and Neural Regeneration in a Spinal Cord Injury Model].
Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Objective: To investigate the regulatory mechanism of a circular RNA (circRNA), circ_001146, on the miR-1200/SP1 axis in spinal cord injury (SCI). Methods: In the animal model, male Sprague-Dawley rats of 8 weeks old, weighing 220-250 g, were randomly assigned to 5 groups ( Results: In the animal experiment, at 21 and 28 days post surgery, the sh-circ_0011462 group exhibited significantly higher BBB scores (7.00 ± 1.20 and 10.00 ± 2.21) and TFL scores (1.21 ± 0.41 and 1.19 ± 0.31) compared with the SP1 overexpression group (BBB: 5.00 ± 0.60 and 6.00 ± 0.80; TFL: 0.80 ± 0.25 and 0.70 ± 0.20) and the SCI group (BBB: 4.00 ± 0.60 and 5.00 ± 0.70; TFL: 0.60 ± 0.21 and 0.50 ± 0.18) (all Conclusion: circ_001146 may target and modulate the miR-1200/SP1 axis to ameliorate the pathological conditions of SCI, thereby reducing inflammatory responses, inhibiting neuronal apoptosis, and promoting neural regeneration.
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