ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2025
[Construction and Clinical Validation of a Risk Early Warning Model for Mechanical Ventilation-Associated Pneumonia in Older Patients With Lung Cancer].
Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To establish and validate a risk prediction model for mechanical ventilator-associated pneumonia (VAP) in older patients with lung cancer. Methods: A total of 548 older patients with lung cancer were enrolled between January 2022 and May 2025. Subsequently, the patients were divided into a training set ( Results: A total of 153 participants (39.84%) in the training set and 65 participants (39.63%) in the validation set developed VAP. Univariate analysis revealed that such factors as age, lung cancer stage, mechanical ventilation duration, Acute Physiologic Assessment and Chronic Health Evaluation (APACHE) Ⅱ score, procalcitonin (PCT), pentraxin 3 (PTX3), retinol-binding protein (RBP), soluble triggering receptor expressed on myeloid cells-1 (STREM-1), and human cartilage glycoprotein-39 (YKL-40) were associated with VAP in older lung cancer patients ( Conclusion: Age, mechanical ventilation duration, APACHE Ⅱ score, and serum levels of PTX3, RBP, and STREM-1 are all predictors for the occurrence of VAP in older lung cancer patients. The nomogram model constructed based on these factors demonstrates acceptable predictive performance.
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