Evidence map›Paper›PMID 41536616›Full record

ArticleOpen forum infectious diseases2026

Clinical Features and Mortality of Chronic Pulmonary Aspergillosis in Brazil: a Multicenter Cohort Study.

Vítor Falcão de Oliveira, João Antonio Gonçalves Garreta Prats, Valdes Roberto Bollela, Alessandro Comarú Pasqualotto, Diego Rodrigues Falci, Marcio Nucci, Flavio Queiroz-Telles, Fernanda Guioti Puga, Maria Daniela Bergamasco, Guilherme Santoro-Lopes and 5 more

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Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Vítor Falcão de OliveiraDivision of Infectious Diseases, Hospital das Clínicas da Faculdade de Medicina, University of São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-2097-389X
João Antonio Gonçalves Garreta PratsDepartment of Medicine, Division of Infectious Diseases, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Valdes Roberto BollelaDivision of Infectious Diseases, Internal Medicine Department, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
Alessandro Comarú PasqualottoUniversidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil.ORCID https://orcid.org/0000-0002-6782-5395
Diego Rodrigues FalciHospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.ORCID https://orcid.org/0000-0002-8683-3833
Marcio NucciDepartment of Internal Medicine, University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0003-4867-0014
Flavio Queiroz-TellesDepartment of Public Health, Federal University of Paraná, Curitiba, Brazil.
Fernanda Guioti PugaDivision of Infectious Diseases, Internal Medicine Department, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
Maria Daniela BergamascoDepartment of Medicine, Division of Infectious Diseases, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-5795-1785
Guilherme Santoro-LopesDepartment of Internal Medicine, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Denise Silva RodriguesInstituto Clemente Ferreira, Secretaria de Estado da Saude, São Paulo, Brazil.
Valério Rodrigues AquinoHospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Marcello Mihailenko Chaves MagriDivision of Infectious Diseases, Hospital das Clínicas da Faculdade de Medicina, University of São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-7996-8265
David W DenningManchester Fungal Infection Group, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.ORCID https://orcid.org/0000-0001-5626-2251
Arnaldo L ColomboDepartment of Medicine, Division of Infectious Diseases, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Data on clinical characteristics and prognosis of chronic pulmonary aspergillosis (CPA) in resource-limited, high tuberculosis (TB) burden settings, especially in Brazil, remain scarce. Methods: This multicenter retrospective study evaluated all CPA cases diagnosed between 2012 and 2018 across eight centers in Brazil, examining clinical presentation, diagnosis, treatment, mortality, and factors associated with death, including differences related to pulmonary TB. To identify independent predictors of mortality, we conducted multivariate Cox regression. One-year mortality was analyzed using Kaplan-Meier survival curves. Results: A total of 191 CPA cases were diagnosed, with a median age of 50 years (IQR 40-59) and 62% were male. TB was the most frequent predisposing condition ( Conclusions: In Brazil, the mortality of CPA was lower compared with that reported in previous studies, particularly among patients with TB. In TB-endemic, resource-limited settings, overlapping clinical and radiological features may delay diagnosis and antifungal treatment.

Indexed as

chronic pulmonary aspergillosismortalitytuberculosis

Identifiers

PMID41536616
PMCPMC12798536

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.