Evidence map›Paper›PMID 41536567›Full record

ArticleAgeing and neurodegenerative diseases2022

Selective expression of neurodegenerative diseases-related mutant p150

Jia Yu, Carmelo Sgobio, Xuan Yang, Yu Peng, Xi Chen, Lixin Sun, Hoon Shim, Huaibin Cai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ageing and neurodegenerative diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Deficiency of Perry syndrome-associated p150NPJ Parkinson's disease · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jia YuBasic Research Center, Institute for Geriatrics and Rehabilitation, Beijing Geriatric Hospital, Beijing 100095, China.
Carmelo SgobioTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Xuan YangBasic Research Center, Institute for Geriatrics and Rehabilitation, Beijing Geriatric Hospital, Beijing 100095, China.
Yu PengBasic Research Center, Institute for Geriatrics and Rehabilitation, Beijing Geriatric Hospital, Beijing 100095, China.
Xi ChenTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Lixin SunTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Hoon ShimTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Huaibin CaiTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

Funding

LONGITUDINAL ANALYSIS OF AGE RELATED MEMORY DECLINEK23AG000946 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SMALL, SCOTT A · 2000 to 2004
$640k
The Function of dynactin p150glued in Axonal Transport and Motor Neuron DiseasesZ01AG000946 · NIA · NATIONAL INSTITUTE ON AGING · PI CAI, HUAIBIN · 2008 to 2008
$155k
Intramural NIH HHS Z01 AG000946NIA NIH HHS K23 AG000946
6 · The paper itself

Abstract

Aim: Missense mutations of dynactin subunit p150 Methods: Using a tetracycline-controlled transcriptional regulation system, transgenic mouse models were generated with selective overexpression of wild-type, motor neuron disease-related G59S mutant, or Perry syndrome-related G71R mutant human p150 Results: Compared with non-transgenic control mice, transgenic mice overexpressing wild-type human p150 Conclusion: These findings demonstrate that selective expression of either G59S or G71R mutant p150

Indexed as

DCTN1 genedynactin subunit p150Gluedmidbrain dopaminergic neuronmissense mutationmotor neuron diseaseneurodegenerationnigrostriatal pathwayPerry syndrome

Identifiers

PMID41536567
PMCPMC12797871

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.