Evidence map›Paper›PMID 41536548›Full record

ArticleRSC medicinal chemistry2026

Integrated computational screen and validation of thalidomide-based PROTACs targeting SARS-CoV-2 main protease.

Li-Na Guo, Yu-Hua Li, Rou-Yu Zhu, Ni Su, Zhi-Yu Shao, Hua Diao

Abstract read
In one paragraph

Article in RSC medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Li-Na GuoNHC Key Lab of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies Shanghai 200237 China guoln90@126.com li_yuhua@163.com diaohua@sibpt.cn.
Yu-Hua LiNHC Key Lab of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies Shanghai 200237 China guoln90@126.com li_yuhua@163.com diaohua@sibpt.cn.
Rou-Yu ZhuCollege of Chemistry and Chemical Engineering, Donghua University Shanghai 201620 China chinofield@163.com 1774507481@qq.com zyshao@dhu.edu.cn.
Ni SuCollege of Chemistry and Chemical Engineering, Donghua University Shanghai 201620 China chinofield@163.com 1774507481@qq.com zyshao@dhu.edu.cn.
Zhi-Yu ShaoCollege of Chemistry and Chemical Engineering, Donghua University Shanghai 201620 China chinofield@163.com 1774507481@qq.com zyshao@dhu.edu.cn.
Hua DiaoNHC Key Lab of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies Shanghai 200237 China guoln90@126.com li_yuhua@163.com diaohua@sibpt.cn.ORCID https://orcid.org/0000-0003-2052-6301

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The persistent evolution of SARS-CoV-2 underscores the need for antiviral strategies. The viral main protease (M

Identifiers

PMID41536548
PMCPMC12797135

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.