Evidence map›Paper›PMID 41536519›Full record

ArticleMedComm2026

Emestrin-Type Epidithiodiketopiperazines Inhibited Gasdermin D-Mediated Pyroptosis via Caspase-3/7 Activation.

Bingchuan Geng, Shuang Lin, Wai Yen Yim, Weiguang Sun, Xiaotian Zhang, Cao Ma, Zhiwen Zhang, Quan Guo, Jie Gao, Hanxiao Zeng and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The gasdermin family: from pyroptosis mechanisms to therapeutic targets.Signal transduction and targeted therapy · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Bingchuan GengHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Shuang LinHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Wai Yen YimDepartment of Cardiovascular Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Weiguang SunHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Xiaotian ZhangHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Cao MaFuwai Central China Cardiovascular Hospital Central China Fuwai Hospital of Zhengzhou University Zhengzhou China.
Zhiwen ZhangFuwai Central China Cardiovascular Hospital Central China Fuwai Hospital of Zhengzhou University Zhengzhou China.
Quan GuoFuwai Central China Cardiovascular Hospital Central China Fuwai Hospital of Zhengzhou University Zhengzhou China.
Jie GaoHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Hanxiao ZengHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Qingyi TongHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy Tongji Medical College, Huazhong University of Science and Technology Wuhan China.ORCID https://orcid.org/0000-0001-7713-7230
Yixuan WangDepartment of Cardiovascular Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Zhengfeng FanDepartment of Cardiovascular Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Jincheng HouDepartment of Cardiovascular Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Muwei LiFuwai Central China Cardiovascular Hospital Central China Fuwai Hospital of Zhengzhou University Zhengzhou China.
Yonghui ZhangHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Zhengxi HuHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy Tongji Medical College, Huazhong University of Science and Technology Wuhan China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis, a life-threatening dysregulated host response to infection, is frequently exacerbated by pyroptosis-a programmed, proinflammatory cell death process mediated by Gasdermin D (GSDMD) activation. Using high-throughput screening, we identified emestrin-type epidithiodiketopiperazines (ETPs) as potent inhibitors of GSDMD cleavage during pyroptosis in Tohoku Hospital Pediatrics-1 (THP-1, a human acute monocytic Leukemia cell line)-derived macrophages. Combined surface plasmon resonance and western blotting analyses demonstrated that these ETPs activate caspase-3/7, which in turn cleaves GSDMD at aspartic acid residue 87 to generate a p10 fragment. This process prevents the formation of the pore-forming p30 fragment, thereby mitigating its associated inflammatory effects. Building on these results, in vivo studies showed that a low dose of the lead emestrin-type ETP (compound

Indexed as

apoptosisgasdermin Dhigh‐throughput screeningpyroptosissepsis

Identifiers

PMID41536519
PMCPMC12796841

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.