Evidence map›Paper›PMID 41536494›Full record

ArticleCardiovascular therapeutics2026

Subclinical Hypothyroidism as a Risk for Coronary Artery Bypass Grafting.

Ricardo Mendes Martins, Felipe José M Pittella, Beatriz C de Oliveira, Bernardo G S Lima, Caio C Ferreira, Aline D Pereira, Wolney A Martins, Rubens A C Filho, Giovanna A B Lima

Abstract read
In one paragraph

Article in Cardiovascular therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ricardo Mendes MartinsDepartment of Internal Medicine, Federal Fluminense University, Niteroi, Rio de Janeiro, Brazil, uff.br.ORCID https://orcid.org/0009-0006-6446-8544
Felipe José M PittellaCoronary Disease Unit, National Institute of Cardiology, Rio de Janeiro, Rio de Janeiro, Brazil, cardiologia.org.mx.ORCID https://orcid.org/0009-0000-2133-1851
Beatriz C de OliveiraDepartment of Internal Medicine, Federal Fluminense University, Niteroi, Rio de Janeiro, Brazil, uff.br.ORCID https://orcid.org/0000-0002-0534-0050
Bernardo G S LimaDepartment of Internal Medicine, Federal Fluminense University, Niteroi, Rio de Janeiro, Brazil, uff.br.ORCID https://orcid.org/0009-0005-5237-8894
Caio C FerreiraDepartment of Internal Medicine, Federal Fluminense University, Niteroi, Rio de Janeiro, Brazil, uff.br.ORCID https://orcid.org/0000-0002-6489-1901
Aline D PereiraInstitute of Geography, Rio de Janeiro State University (UERJ), Cabo Frio, Rio de Janeiro, Brazil, uerj.br.ORCID https://orcid.org/0000-0002-5687-1679
Wolney A MartinsDepartment of Internal Medicine, Federal Fluminense University, Niteroi, Rio de Janeiro, Brazil, uff.br.ORCID https://orcid.org/0000-0002-2284-8251
Rubens A C FilhoDepartment of Internal Medicine, Federal Fluminense University, Niteroi, Rio de Janeiro, Brazil, uff.br.ORCID https://orcid.org/0000-0002-5083-4543
Giovanna A B LimaDepartment of Internal Medicine, Federal Fluminense University, Niteroi, Rio de Janeiro, Brazil, uff.br.ORCID https://orcid.org/0000-0002-1815-9373

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The relationship between hypothyroidism and cardiovascular disease is well established. However, data on subclinical hypothyroidism (SH) and its impact on major adverse cardiovascular events (MACEs) and postoperative complications following coronary artery bypass grafting (CABG) remain limited. This study was aimed at evaluating whether SH is associated with an increased risk of these outcomes. Methods: From 2010 to 2019, 863 patients who underwent CABG for cardiovascular diseases at a reference center were included. The primary outcomes included MACE (composite and individual events: all-cause death, cardiovascular death, stroke, acute myocardial infarction [AMI], and new revascularization) and postoperative complications, including atrial fibrillation (AF), pleural effusion (PLE), pericardial effusion (PCE), infections at any site (IASs), and mediastinitis. Results: SH patients had higher rates of MACE (20.3% vs. 8.2%, Conclusions: SH patients who underwent CABG had a higher frequency of MACE and postoperative complications than those of euthyroid patients.

Indexed as

Coronary Artery BypassCoronary Artery DiseaseHypothyroidismPostoperative ComplicationsAgedAsymptomatic DiseasesFemaleHumansMaleMiddle AgedRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment Outcome

Identifiers

PMID41536494
PMCPMC12796499

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.