ReviewChemical science2026
The role of cytosine modification symmetry in mammalian epigenome regulation.
Review in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- DNA Methylation as a Programmable Information Layer: From Molecular Marks to Disease State Engineering.International journal of molecular sciences · 2026Review
- HM-DyadCap - capture and mapping of 5-hydroxymethylcytosine/5-methylcytosine CpG dyads in mammalian DNA.Nucleic acids research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
5-Methylcytosine (mC) is a key regulatory element of mammalian genomes, and plays important roles in development and disease. mC is predominantly written onto CpG dyads by DNA methyltransferases, and can be further oxidized by ten-eleven translocation dioxygenases (TETs) to 5-hydroxymethyl-, 5-formyl-, and 5-carboxylcytosine. This process results in different symmetric and asymmetric combinations of cytosine forms across the two strands of CpGs, each of which represents a unique physicochemical signature in the major groove of DNA. A comprehensive understanding of the individual functions of oxidized mC modifications can therefore only be achieved by considering both strands of CpG dyads. Here, we provide a brief overview of the current state of knowledge on the sequencing and mapping of individual CpG dyad states, their influence on the intrinsic properties of DNA, and their interactions with chromatin proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.