ArticleOsteoarthritis and cartilage open2026
Histological analysis of age-related degeneration in human female and male knee cartilage and meniscus.
Article in Osteoarthritis and cartilage open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Degeneration dependent changes in human knee cartilage mechanical properties revealed by synchrotron tomography based finite element modeling.Osteoarthritis and cartilage open · 2026Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To assess level of degeneration in human knee cartilage and meniscus in donors without clinically-evident knee arthritis, in relation to age and sex. Further, to investigate the association between cartilage and meniscus degeneration. Design: Histological sections of knee cartilage and meniscus from 44 deceased donors (ages 18-85 years) without clinically-evident osteoarthritis or inflammatory arthritis were assessed for the level of degeneration using OARSI grades (cartilage) and modified Pauli scores (meniscus). We used Poisson regression models with robust standard errors to investigate the association of age and sex with grades/scores, and the association between cartilage and meniscus degeneration. Results: Mean [median] (standard deviation) OARSI grade and Pauli score were 2.2 [1.8] (1.2) and 8.2 [8] (2.5), respectively. The mean OARSI grade increased by a factor of 1.19 (95 % confidence interval 1.11 to 1.28) per 10 years of age, and the Pauli score by 1.10 (1.07-1.14). Males had on average 1.29 (0.99-1.69) higher OARSI grades than females, and 1.11 (0.96-1.28) higher Pauli scores. The crude association between Pauli score and OARSI grade was 1.12 (1.05-1.18), while the age and sex adjusted association was 1.06 (0.99-1.13). Conclusions: Tissue degeneration assessed by OARSI grades and modified Pauli scores increase with age in persons without clinically-evident knee arthritis. However, about half of the elderly donors show only mild degeneration. There was a small association between degeneration and male sex, for both tissues. Cartilage and meniscus degeneration within knees without clinically-evident arthritis were weakly associated.
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