ArticleCureus2025
Granulomatous Lymphocytic Interstitial Lung Disease as the Initial Manifestation of Common Variable Immunodeficiency in a Young Adult.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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0 citing papers in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Common variable immunodeficiency (CVID) is a primary immunodeficiency that often goes unrecognized until adolescence or adulthood. Granulomatous-lymphocytic interstitial lung disease (GLILD) is a non-infectious pulmonary complication of CVID that can be subtle, sometimes presenting before significant infections or systemic symptoms. A 19-year-old female patient presented with mild flu-like symptoms. Examination revealed splenomegaly, and routine labs showed mild anaemia and thrombocytopenia. Despite rapid recovery from influenza A, persistent splenomegaly prompted further evaluation. Chest CT demonstrated multiple nodules, ground-glass opacities, and mediastinal lymphadenopathy, findings surprisingly disproportionate to her mild symptoms. Her history of recurrent childhood infections, combined with marked hypogammaglobulinemia and abnormal B-cell immunophenotyping (including increased CD21
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