ArticleCureus2025
Precancerous Gallbladder Lesions in Cholelithiasis: A Histopathological Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGallbladder cancer (GBC) is highly prevalent in Northern and Eastern India and often diagnosed late, leading to poor outcomes. Identifying precursor lesions is essential, as the metaplasia-dysplasia-carcinoma sequence plays a central role in gallbladder carcinogenesis. This study examines precancerous mucosal changes in cholelithiasis and evaluates their histopathological patterns and clinical relevance for early detection. MATERIALS AND
methodsThis cross-sectional study included 100 patients with ultrasonography-confirmed cholelithiasis who underwent cholecystectomy at Sir Sunderlal Hospital, Banaras Hindu University. Patients with hepatic or metabolic comorbidities were excluded. Clinical characteristics and hematological and biochemical parameters were recorded. Resected gallbladder specimens were examined for microanatomical and histological alterations. Statistical analysis was performed using IBM Corp. Released 2026. IBM SPSS Statistics for Windows, Version 26. Armonk, NY: IBM Corp., with p<0.05 considered significant.
resultsA total of 100 patients with cholelithiasis were stratified into four clinical severity grades. Of these, 36 were male, and 64 were female. The mean age showed no significant variation across the groups (p = 0.480), indicating a uniform age distribution among the study population. Serum alkaline phosphatase levels showed a marked, statistically significant rise with increasing severity (p < 0.0001). Significant inter-group differences were also observed in hemoglobin, platelet count, bilirubin fractions, total protein, urea, and selected anthropometric parameters (p < 0.05). Histopathological evaluation revealed epithelial hyperplasia as the most common lesion (58%), followed by low-grade dysplasia (22%) and intestinal metaplasia (10%), while normal mucosa was seen in only 10% of cases (p < 0.001). These findings demonstrate a clear progression of microanatomical alterations consistent with the metaplasia-dysplasia-carcinoma sequence.
conclusionChronic cholelithiasis was associated with significant mucosal changes, mainly epithelial hyperplasia, intestinal metaplasia, and low-grade dysplasia, supporting the metaplasia-dysplasia-carcinoma sequence. Alkaline phosphatase levels rose progressively with disease severity, indicating ongoing tissue injury. These findings highlight the importance of routine histopathological examination for early detection of precursor lesions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.