ArticleAdvances in radiation oncology2026
Relationship Between Intestinal Flora and Acute Radiation Enteritis in Patients With Advanced Cervical Cancer Undergoing Concurrent Chemoradiotherapy.
Article in Advances in radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Microbiome-Driven Risk Stratification and Biotherapeutics in Radiation Enteritis.Computational and structural biotechnology journal · 2026Review
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Acute radiation enteritis (RE), particularly diarrhea, remains a major dose-limiting complication in patients with locally advanced cervical cancer (LACC) undergoing concurrent chemoradiotherapy (CCRT). The study investigated the relationship between dynamic intestinal flora alterations and RE-related diarrhea in patients with LACC undergoing CCRT. Methods and Materials: This prospective observational cohort study enrolled 83 patients with LACC receiving CCRT in a hospital setting. The patients were categorized into a Mild group (mild diarrhea, adverse events grade < 2, n = 47) and a Severe group (severe diarrhea, grade ≥ 2, n = 36). Fecal samples were collected at baseline (T0), week 4 (T4), and week 8 (T8) after radiation therapy initiation. 16S rRNA sequencing was performed to analyze the microbial composition. Alpha/beta diversity, taxonomic differences, functional pathways, and correlations with clinical indicators were also evaluated. Results: During CCRT, diarrhea severity peaked at 4 to 5 weeks and gradually decreased in weeks 5 to 8. Significantly decreased alpha diversity at T4 in the Severe group (nadir: 51.10% Firmicutes and 39.10% Bacteroidetes) was partially restored at T8. Beta diversity revealed clustering between the groups at T4. The relative abundances of f__Bacteroidaceae, g__ Conclusions: Acute RE-related diarrhea severity in patients with cervical cancer undergoing CCRT is associated with intestinal dysbiosis. Severe diarrhea was correlated with reduced alpha diversity, lower Firmicutes/Bacteroidetes ratio, and enriched proinflammatory taxa.
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