Evidence map›Paper›PMID 41536208›Full record

ArticleAmerican journal of epidemiology2026

Exploring the association between higher education and steeper cognitive decline in a nationally representative longitudinal study in India.

Emma Nichols, Richard N Jones, Alden L Gross, Eleanor Hayes-Larson, Erik Meijer, Miguel Arce Renteria, Lindsay C Kobayashi, Jinkook Lee

Abstract read
In one paragraph

Article in American journal of epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Emma NicholsCenter for Economic and Social Research, University of Southern California, Los Angeles, CA, United States.ORCID 0000-0002-9005-3872
Richard N JonesDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, RI, United States.ORCID 0000-0002-1049-218X
Alden L GrossDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Eleanor Hayes-LarsonLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States.ORCID 0000-0001-8299-2389
Erik MeijerCenter for Economic and Social Research, University of Southern California, Los Angeles, CA, United States.
Miguel Arce RenteriaDepartment of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY, United States.
Lindsay C KobayashiDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, United States.ORCID 0000-0003-2725-3107
Jinkook LeeCenter for Economic and Social Research, University of Southern California, Los Angeles, CA, United States.ORCID 0000-0002-6209-719X

Funding

Leveraging a natural experiment to estimate the causal impact of blood sugar on dementia and cognition in IndiaR01AG051125 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Jinkook Lee · 2015 to 2026
$26.8M
Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Study of India (LASI)-Genomic study.U01AG064948 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KARDIA, SHARON L, LEE, JINKOOK · 2019 to 2023
$12.5M
Socioeconomic, Cardiovascular, and Psychosocial Sources of Cross-National Variation in Cognitive Health Among Older AdultsR01AG070953 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alden L. Gross, Lindsay C Kobayashi · 2021 to 2026
$4.6M
NIA NIH HHS R01 AG051125NIA NIH HHS U01 AG064948NIH HHS 3R01 AG030153NIH HHS R01 AG051125NIH HHS R01 AG070953NIH HHS RF1AG0887965
6 · The paper itself

Abstract

Evidence on the association between education and cognitive decline is mixed. Recent systematic reviews suggest no association, but most evidence comes from high-income contexts. We used data from the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (N = 3673; 2017-2024) to estimate the association between educational attainment and cognitive decline using linear mixed effects models. We evaluated findings across a range of models and explored the roles of practice effects, selective survival, and assumptions about the underlying causal structure using supplementary analyses. Despite large differences in cognitive level (those with higher education had higher cognition in wave 1), compared to those with no education, those with less than primary school (difference of -0.03 SD units/year; 95% CI, -0.04 to -0.01), primary school (-0.04; -0.06 to -0.03), middle-secondary school (-0.06; -0.07 to -0.04), and higher secondary school or above (-0.05; -0.07 to -0.03) had steeper cognitive decline after adjustment for demographic and early-life socioeconomic factors. Neither practice effects nor selective survival could explain findings, though findings were consistent with one of the two simulated causal structures. Analyses illustrate challenges in analyzing longitudinal cognitive data and showcase potential approaches to rule out methodological explanations and probe results.

Indexed as

Cognitive DysfunctionEducational StatusFemaleHumansIndiaLongitudinal StudiesMaleSocioeconomic Factorscognitive declineeducationIndiapractice effectssimulationsurvival bias

Identifiers

PMID41536208
PMCPMC13231860

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.