Evidence map›Paper›PMID 41536053›Full record

ArticleJournal of integrative plant biology2026

GeARF5/GeIAA33-GeSWEET14 module balances the secondary metabolic biosynthesis to increase the yield and quality in Gastrodia elata.

Qun Liu, Zhiqing Wu, Yugang Gao, Yue Xu, Pu Zang, Xinyu Yang, Yan Zhao, Pan Liao, Benoît Boachon, Guoyin Kai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of integrative plant biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qun LiuLaboratory of Medicinal Plant Cultivation and Breeding, National Administration of Traditional Chinese Medicine, College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.ORCID https://orcid.org/0000-0002-6828-4973
Zhiqing WuLaboratory of Medicinal Plant Cultivation and Breeding, National Administration of Traditional Chinese Medicine, College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.ORCID https://orcid.org/0009-0002-6594-3192
Yugang GaoLaboratory of Medicinal Plant Cultivation and Breeding, National Administration of Traditional Chinese Medicine, College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.ORCID https://orcid.org/0000-0001-5510-5895
Yue XuLaboratory of Medicinal Plant Cultivation and Breeding, National Administration of Traditional Chinese Medicine, College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.ORCID https://orcid.org/0000-0003-0473-1284
Pu ZangLaboratory of Medicinal Plant Cultivation and Breeding, National Administration of Traditional Chinese Medicine, College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.ORCID https://orcid.org/0000-0003-1130-7502
Xinyu YangLaboratory of Medicinal Plant Cultivation and Breeding, National Administration of Traditional Chinese Medicine, College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.ORCID https://orcid.org/0009-0005-6188-5492
Yan ZhaoLaboratory of Medicinal Plant Cultivation and Breeding, National Administration of Traditional Chinese Medicine, College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.ORCID https://orcid.org/0000-0003-0704-7410
Pan LiaoDepartment of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, SAR 999077, China.ORCID https://orcid.org/0000-0002-1156-8916
Benoît BoachonLaboratoire de Biotechnologies Végétales appliquées aux Plantes Aromatiques et Médicinales, CNRS, LBVpam UMR 5079, Université Jean Monnet, Saint-Étienne, F-42023, France.ORCID https://orcid.org/0000-0002-2362-2238
Guoyin KaiZhejiang International Science and Technology Cooperation Base for Active Ingredients of Medicinal and Edible Plants and Health, College of Pharmacy, Jinhua Academy, Zhejiang Chinese Medical University, Hangzhou, 310053, China.ORCID https://orcid.org/0000-0001-7586-9067

Funding

Fund of Jiangsu Key Laboratory for the Research and Utilization of Plant Resources JSPKLB202201Jiangsu Institute of Botany Talent Fund JIBTF202201the National Key Research and Development Program of China 2022YFF1300503-04the National Key Research and Development Program of China 2023YFC3503900the Science and Technology Development Program of Jilin Province 20210401093YYthe Science and Technology Development Program of Jilin Province 20220401110YY
6 · The paper itself

Abstract

Gastrodia elata is an important edible and medicinal plant, and its yield is a significant factor limiting the industry's development. The number of branches produced by vegetative propagation corms (VPCs) is a limiting factor for the yield of G. elata. Hormonal signals, along with sucrose and starch biosynthesis, are key factors potentially influencing VPC formation. However, the mechanisms underlying VPC formation in G. elata remain poorly understood. In this study, we identified a member of the SWEET family, GeSWEET14, through single-stem/multi-stem (SS/MS) transcriptome screening. GeSWEET14 has the potential to increase both VPC formation and the yield of G. elata by promoting sucrose and starch biosynthesis while simultaneously reducing gastrodin biosynthesis. Further results demonstrated that the auxin increases the VPC formation by activating GeARF5-GeSWEET14 expression. In contrast, the auxin signaling inhibitor GeIAA33 was found to be upregulated in the OE-GeSWEET14 transgenic lines. GeIAA33 interacts with GeARF5 both in vivo and in vitro, attenuating its transcriptional activation of GeSWEET14 and thus establishing a feedback regulatory mechanism. Moreover, GeARF5 promotes the accumulation of sucrose and starch by binding to the promoters of GeISA3 and GeglgB1. Additionally, GeARF5 enhances gastrodin biosynthesis by binding to the promoters of GePAL1 and GeGT3-1. Collectively, these findings elucidate the role of the GeARF5/GeIAA33-GeSWEET14 module in VPC formation and secondary metabolite accumulation, providing a foundation for the genetic improvement of G. elata germplasm resources.

Indexed as

GastrodiaPlant ProteinsBenzyl AlcoholsGene Expression Regulation, PlantGlucosidesIndoleacetic AcidsPlants, Genetically ModifiedSucroseBenzyl AlcoholsgastrodinGlucosidesIndoleacetic AcidsPlant ProteinsSucroseGastrodia elatagastrodin biosynthesisGeARF5GeSWEET14sucrose and starch biosynthesis

Identifiers

PMID41536053
PMCPMC13084217

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.