Evidence map›Paper›PMID 41535964›Full record

ArticleTrials2026

The cumulative physiological effects of consecutive days of simulated occupational heat stress: study protocol for a randomised controlled trial with healthy adults undertaken in Australia.

Luana C Main, Daniel C Moore, Jarrad Lum, Ben Lee, Sean L Corrigan, Brad Aisbett, Sean R Notley

Abstract read
In one paragraph

Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Luana C MainInstitute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia. luana.main@deakin.edu.au.ORCID http://orcid.org/0000-0002-9576-9466
Daniel C MooreInstitute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia.ORCID http://orcid.org/0000-0001-9701-4991
Jarrad LumSchool of Psychology, Faculty of Health, Deakin University, Geelong, Australia.ORCID http://orcid.org/0000-0003-2098-2403
Ben LeeCentre for Sport, Exercise and Life Sciences (CSELS) Research Centre, Faculty of Health and Life Sciences, Coventry University, Coventry, UK.ORCID http://orcid.org/0000-0001-6826-7463
Sean L CorriganInstitute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia.ORCID http://orcid.org/0000-0003-1986-854X
Brad AisbettInstitute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia.ORCID http://orcid.org/0000-0001-8077-0272
Sean R NotleyDefence Science and Technology Group, Melbourne, Australia.ORCID http://orcid.org/0000-0002-5065-5000

Funding

Defence Science and Technology Group ID12114
6 · The paper itself

Abstract

backgroundFuelled by rising global temperatures, occupational heat stress has become a critical threat to the health and safety of workers. This threat may be particularly great for workers who are required to perform prolonged work in the heat over multiple consecutive days; however, the cumulative physiological impact of these work conditions remains unclear. As such, the primary objective of this study is to determine the effects of three consecutive simulated physically demanding workdays in a hot and humid environment on core temperature (primary outcome), with secondary objectives examining the impact on heart rate, hydration status, physical task performance, and cognitive function.

methodsThe study will involve an open-label exploratory randomised within-subject cross-over experimental trial, lasting 74 h. All trials will be conducted at Deakin University, Australia, in a climate-controlled environmental chamber. Participants will complete three consecutive days of simulated physically demanding work. Participants will be healthy, physically active male and female non-smokers aged 18-40 years, with a body mass index (BMI) < 35 kg·m DISCUSSION: Growing evidence indicates that working in the heat on consecutive days, a common situation for many workers, may lead to a cumulative increase in the physiological strain on the body. This will commensurately increase the risk of heat-related injuries while also increasing susceptibility to a range of health issues. Our findings will inform whether current heat management practices need to be adjusted to consider the impact of repeated heat exposures. Australian New Zealand Clinical Trials Registry,  https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=386410 ; First planned enrolment 15/04/2024.

trial registrationACTRN12623001069640. Registered on 06/10/2023.

Indexed as

Heat-Shock ResponseHeat Stress DisordersHot TemperatureOccupational DiseasesOccupational ExposureOccupational HealthAdolescentAdultAustraliaBody Temperature RegulationCognitionCross-Over StudiesFemaleHeart RateHumansHumidityClimate changeEnvironmental healthHeat illnessHotPhysiologyWork

Identifiers

PMID41535964
PMCPMC12888555

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.