Evidence map›Paper›PMID 41535949›Full record

ArticleGenome biology2026

VIST: variational inference for single cell time series.

Bingxian Xu, Rosemary Braun

Abstract read
In one paragraph

Article in Genome biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Bingxian XuDepartment of Molecular Biosciences, Northwestern University, Evanston, 60208, IL, USA.
Rosemary BraunDepartment of Molecular Biosciences, Northwestern University, Evanston, 60208, IL, USA. rbraun@northwestern.edu.

Funding

Reconstructing the temporal landscape of gene regulation in agingR01AG068579 · NIA · NORTHWESTERN UNIVERSITY · PI BRAUN, ROSEMARY · 2020 to 2024
$2.0M
National Science Foundation DMS-1764421NIA NIH HHS R01 AG068579NIH HHS R01AG068579Simons Foundation 597491
6 · The paper itself

Abstract

Time course single-cell RNA sequencing (scRNA-seq) enables researchers to probe expression dynamics at the resolution of individual cells. Analyzing this data poses several challenges, including deconvolving the contributions of time and cell type, discriminating true dynamics from batch effects, and inferring per-cell dynamics despite cells being destroyed at each time point. We present VIST (Variational Inference for Single cell Time series), a deep-learning algorithm that deconvolves single-cell time series into time-dependent and time-independent components. Using both synthetic and real scRNA-seq data, we show that VIST constructs biologically meaningful latent spaces, removes batch effects, and generates realistic single-cell time series.

Indexed as

AlgorithmsSequence Analysis, RNASingle-Cell AnalysisAnimalsHumansSingle-Cell Gene Expression AnalysisBatch correctionGene expression time seriesSingle-cell RNA-seqVariational inference

Identifiers

PMID41535949
PMCPMC12892444

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.