High-dose corticosteroid application in acute severe nickel carbonyl poisoning: a case series of three occupational exposures and their recovery outcomes.

Yixin Chen, Zhuo Yang, Yuqi Xiao, Min Chai, Hongwei Long, Dahai Xu, Chang Su

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Article in BMC pulmonary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Yixin Chen *Department of Emergency Medicine, The First Hospital of Jilin University, No. 1 Xinmin Street, Chaoyang District, Changchun, 130000, Jilin, China.

Zhuo Yang *Department of Emergency Intensive Care Unit, The First Hospital of Jilin University, Changchun, 130000, Jilin, China.

Yuqi XiaoDepartment of Emergency Medicine, The First Hospital of Jilin University, No. 1 Xinmin Street, Chaoyang District, Changchun, 130000, Jilin, China.

Min ChaiDepartment of Emergency Medicine, The First Hospital of Jilin University, No. 1 Xinmin Street, Chaoyang District, Changchun, 130000, Jilin, China.

Hongwei LongDepartment of Neurosurgery, Meihekou Central Hospital, Changchun, 130000, Jilin, China.

Dahai XuDepartment of Emergency Medicine, The First Hospital of Jilin University, No. 1 Xinmin Street, Chaoyang District, Changchun, 130000, Jilin, China. xudahai0319@jlu.edu.cn.

Chang SuDepartment of Thyroid Surgery, The First Hospital of Jilin University, No. 1 Xinmin Street, Chaoyang District, Changchun, 130000, Jilin, China. suchang1@jlu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute severe nickel carbonyl poisoning is an uncommon yet potentially fatal occupational hazard that produces marked pulmonary injury and rapidly progressive respiratory failure. CASE PRESENTATION: We describe three middle-aged men who developed severe nickel carbonyl intoxication after workplace exposure at a metal-processing facility. All patients presented with progressive dyspnea, cyanosis, hypoxemia, and pronounced neutrophilia. Chest computed tomography revealed bilateral pulmonary infiltrates with variable early distribution across patients. Prompt recognition permitted immediate initiation of high-dose methylprednisolone, moxifloxacin, and individualized supportive care according to oxygen (O

conclusionsNickel carbonyl exposure demanded a high index of suspicion and prompt initiation of high-dose corticosteroid therapy was required to prevent irreversible lung injury and improve survival. This case series provides valuable clinical evidence to inform diagnostic and therapeutic approaches for this rare occupational poisoning.

Indexed as

GlucocorticoidsMethylprednisoloneNickelOccupational ExposureHumansMaleMiddle AgedMoxifloxacinTomography, X-Ray ComputedTreatment OutcomeGlucocorticoidsMethylprednisoloneMoxifloxacinNickelCase reportsCorticosteroid therapyNickel carbonyl poisoningOccupational exposurePulmonary toxicity

Identifiers

PMID41535844

DOI10.1186/s12890-026-04112-6

PMCPMC12892430

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.