Trial reportBMC anesthesiology2026
Conscious analgesia with oxycodone improves the efficacy and safety in patients at high risk of aspiration during gastroscopy: a randomized double-blind trial.
Trial report in BMC anesthesiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- An Oxycodone-Based Conscious Analgesia Strategy with Supplemental Low-Dose Propofol Improves Safety in Elderly Obese Patients Undergoing Gastroscopy: A Prospective Randomized Controlled Trial.Drug design, development and therapy · 2026Trial
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundFor the patients at high-risk of aspiration, general anesthesia may increase the risk of aspiration, while local pharyngeal anesthesia may cause extreme discomfort and even failure of gastroscopy. In this study, we tested the efficacy and safety of conscious analgesia with oxycodone in these patients.
methodsIn this prospective, randomized, double-blind, parallel-controlled trial, the patients were randomly assigned to either the oxycodone group (group O) or the 0.9% saline group (group C). Before the gastroscope insertion, group O received oxycodone (0.05 mg/kg), while group C received an equivalent volume of 0.9% normal saline. In cases where initial gastroscope insertion failed, a rescue dose of propofol (0.5 mg/kg) was administered. The success rate of the first gastroscopy placement, the number of gastroscope insertion and rescue propofol, total consumption of propofol, duration of the procedure, patient tolerance, perioperative adverse events, the satisfaction of patients and endoscopists were compared.
resultsA total of 175 patients were recruited, and no patient experienced aspiration. The success rate of initial gastroscope insertion and the satisfaction of patients and endoscopists in group O were higher than those in group C (P < 0.001). The number of gastroscope insertion, rescue times and total consumption of propofol, duration of the procedure, the behavioral pain scale non-intubated (BPS-NI) at the time of initial gastroscope insertion, intraoperative retching, limb movement, and tachycardia in group O were significantly lower than those in group C (all P < 0.001).
conclusionConscious analgesia with oxycodone could help some patients at high risk of aspiration to complete the gastroscopy effectively and safely.
trial registrationRegistered in the Chinese Clinical Trial Registry (ChiCTR-2100053142 ) on November 13, 2021.
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