Evidence map›Paper›PMID 41535707›Full record

ArticleActa pharmacologica Sinica2026

G protein-dependent dopamine D2 receptor signaling mediates cocaine-primed reinstatement.

Hai-Bo Li, Yong-Hui Liu, Hai Liu, Yuan Li, Qiu-Min Le, Fei-Fei Wang, Lan Ma, Xing Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmacologica Sinica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hai-Bo Li *School of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Pharmacology Research Center, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200032, China.
Yong-Hui Liu *School of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Pharmacology Research Center, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200032, China.
Hai LiuSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Pharmacology Research Center, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200032, China.
Yuan LiSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Pharmacology Research Center, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200032, China.
Qiu-Min LeSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Pharmacology Research Center, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200032, China.
Fei-Fei WangSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Pharmacology Research Center, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200032, China.
Lan MaSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Pharmacology Research Center, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200032, China. lanma@fudan.edu.cn.
Xing LiuSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Pharmacology Research Center, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200032, China. xingliu@fudan.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The high relapse rate of drugs is currently a therapeutic dilemma in the treatment of substance use disorder (SUD). Emerging evidence from preclinical animal models demonstrates that pretreatment with selective dopamine D

Indexed as

CocaineCocaine-Related DisordersGTP-Binding ProteinsReceptors, Dopamine D2Signal TransductionAnimalsbeta-ArrestinsCyclic AMPDrug-Seeking BehaviorMaleMiceMice, Inbred C57BLNucleus AccumbensSelf Administrationbeta-ArrestinsCocaineCyclic AMPGTP-Binding ProteinsReceptors, Dopamine D2biased signalingcocainedopamine D2 receptornucleus accumbensreinstatement

Identifiers

PMID41535707
PMCPMC13109425

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.