ArticleScientific reports2026
Utility of prostate-specific antigen derivatives to minimize unnecessary magnetic resonance imaging in patients with prior negative prostate biopsy.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Beyond Total PSA: Clinical Significance of S2,3PSA% in Reducing Unnecessary Prostate Biopsies.International journal of urology : official journal of the Japanese Urological Association · 2026Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Magnetic resonance imaging (MRI) has become an important tool for recommending prostate biopsy (PB) in prostate cancer (PCa) detection. However, the routine use of MRI in patients with previous negative PB remains debatable. This study aimed to evaluate the utility of prostate-specific antigen (PSA) derivatives to guide MRI use and reduce unnecessary scans in such cases. Receiver operating characteristic analysis identified a Prostate Imaging Reporting and Data System score ≥ 4 as the optimal threshold for predicting clinically significant PCa (Gleason score ≥ 7). A cohort of 251 patients with at least one prior negative PB who underwent serum PSA testing, free PSA, and MRI between October 2015 and June 2024 were analyzed. The optimal cutoff values for PSA, PSA density (PSAD), and free-to-total PSA ratio (%fPSA) were 11.87 ng/mL, 0.19 ng/mL
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