SynthesisInternational journal of colorectal disease2026
Prognostic impact of myosteatosis on postoperative outcomes and survival in colorectal cancer: a systematic review.
Synthesis in International journal of colorectal disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- CT-derived myosteatosis as a predictor of postoperative outcomes in esophagogastric cancer surgery: a systematic review.Frontiers in medicine · 2026Pooled it
- Article
- Machine learning based on body composition radiomics for predicting early recurrence in colorectal cancer: a multicenter study.Frontiers in nutrition · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo characterise (1) the definition and measurement methods of myosteatosis, (2) the impact of myosteatosis on post-operative complications (overall, severe complications defined as Clavien-Dindo 3 and above, anastomotic leak, length of stay) in both non-metastatic and metastatic colorectal cancer (CRC) patients and (3) the impact of myosteatosis on long-term survival outcomes in non-metastatic CRC (overall survival, cancer-specific survival, disease-free survival).
methodsA systematic search of Medline, Embase and Cochrane Central databases was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines in 2024.
resultsA total of 4410 publications were initially retrieved; 54 studies fulfilled the inclusion criteria. A variety of measurement methods of myosteatosis were found. There was good quality evidence to support a negative correlation between myosteatosis and overall survival (OS). Colon cancer was more consistently associated with OS and DFS compared to rectal cancer. Myosteatosis was found to significantly impact severe (Clavien-Dindo 3 and above) postoperative complications in colon cancer. Other postoperative outcomes were limited by inconsistency and an overall paucity in volume and quality.
conclusionMyosteatosis has a negative association with OS, with consistent effects observed in colon cancer. There is a negative association with severe postoperative outcomes, particularly in colon cancer. These results are limited by the risk of bias and heterogeneity in measurement methods and statistical analysis. Future work is required to clarify the scan acquisition protocol and diagnostic criteria.
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