ReviewCancer metastasis reviews2026
The diverse roles of Hox proteins in the regulation of the cell cycle and their therapeutic value in cancer treatment.
Review in Cancer metastasis reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- The HOXA gene cluster: a critical regulator in bone-related disorders.Annals of medicine · 2026Review
- HOXC9 promotes cell proliferation and suppresses mitochondria-dependent apoptosis through the AKT/mTOR pathway in esophageal squamous cell carcinoma.Molecular and cellular biochemistry · 2026Article
- Unlocking the HOX: Homeobox Genes as Regulators of Hematopoietic Development.International journal of molecular sciences · 2026Review
- Estradiol Reverses Ovariectomy-Induced Small RNA-mRNA Stress Signatures to Restore Neuroendocrine, Synaptic, and Immune Homeostasis in the Hypothalamus.Biomolecules · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue morphogenesis and homeostasis occur at the interface of a fine coordination between cell cycle and differentiation events. The fundamental role of Hox genes during embryonic development is well established. However, less is known about their role in adult tissues and in contexts other than cellular differentiation. In this review, we focus on the role of Hox proteins in cell cycle-related events in adult tissues and highlight two main cell cycle-permissive and repressive roles for these genes. Given the significance of Hox proteins as a therapeutic target in cancer treatment, we will further discuss the existing approaches in this domain highlighting the challenges that impact the success prospects. For the successful development and application of Hox-oriented anticancer therapies, a comprehensive image of Hox roles in carcinogenic events including their mechanism of function as well as the networks/cascades within which they exert their effects is an inevitable requirement. Moreover, the functional variations of Hox genes in response to changes in the tumour microenvironment along with possible alternations of the mutational landscape in tumours during disease progression should also be taken into account as factors that might impact the therapeutic outcomes of Hox-targeting approaches.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.