Evidence map›Paper›PMID 41535563›Full record

ArticleAnnals of surgical oncology2026

Probe-Based Confocal Laser Endomicroscopy in Gynecologic Surgical Oncology: Intraoperative Insights to Guide Surgical Resection.

Stefano Ferla, Stefano Fucina, Nicolò Clemente, Paola Spessotto, Renato Cannizzaro, Antonino Ditto

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stefano FerlaDivision of Gynaecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero - Universitaria di Bologna, Bologna, Italy.
Stefano FucinaGynecological Oncology Unit, Centro di Riferimento Oncologico Aviano, (CRO) IRCCS, Aviano, Italy. stefano.fucina@gmail.com.ORCID http://orcid.org/0009-0001-2374-7030
Nicolò ClementeGynecological Oncology Unit, Centro di Riferimento Oncologico Aviano, (CRO) IRCCS, Aviano, Italy.
Paola SpessottoMolecular Oncology Unit, Centro di Riferimento Oncologico Aviano, (CRO) IRCCS, Aviano, Italy.
Renato Cannizzaro *Oncological Gastroenterology Unit, Centro di Riferimento Oncologico Aviano, (CRO) IRCCS, Aviano, Italy.
Antonino Ditto *Gynecological Oncology Unit, Centro di Riferimento Oncologico Aviano, (CRO) IRCCS, Aviano, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOvarian cancer is a leading cause of cancer-related death in women. Cytoreductive surgery is the cornerstone of treatment, but frequently requires extensive surgical procedures.

resultsIn vivo pCLE images and subsequent biopsies were acquired from various anatomical sites after injection of fluorescein. Each endomicroscopic sequence was analyzed by dedicated investigators highly experienced in pCLE imaging and compared with the histology of the corresponding specimen. Normal tissues exhibited uniform stromal fibers, consistent cellular architecture, and regular vascularization. In contrast, malignant nodules were identified by fluorescein leakage, reflecting abnormal vessel permeability and highlighting clusters of neoplastic cells.

conclusionsPreliminary data from our observations indicate a substantial concordance between pCLE findings and histology. pCLE is a promising intraoperative tool for real-time cellular analysis.

Indexed as

Carcinoma, Ovarian EpithelialOvarian NeoplasmsSurgery, Computer-AssistedAdultBRCA2 ProteinFemaleHumansLaparoscopyMicroscopy, ConfocalMiddle AgedBRCA2 ProteinBRCA mutationOvarian cancerPeritoneal carcinomatosisProbe-based confocal endomicroscopyProphylactic surgerySTIC lesion

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.